Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜영 | * |
dc.contributor.author | 우현애 | * |
dc.contributor.author | 박지영 | * |
dc.date.accessioned | 2022-06-02T16:32:17Z | - |
dc.date.available | 2022-06-02T16:32:17Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1661-6596 | * |
dc.identifier.other | OAK-31593 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261348 | - |
dc.description.abstract | LPS induces inflammatory cytokines, including IL-1β, IL-6, and TNF-α, and causes an inflammatory response. The development of small molecules that have suppressive effect on those inflammatory cytokines is a desirable strategy for the treatment of inflammatory diseases. We synthesized 12 novel compounds with 4-amino-N-(4-(benzo[d]oxazol-2-ylamino)phenyl)butanamide moiety and evaluated their biological activities. Among them, 4 compounds (compound 5d, 5c, 5f, 5m and synthetic intermediate 4d) showed potent inhibition activities on IL-1β and IL-6 mRNA expression in vitro. Further, in vivo activity was evaluated with two compounds (5f and 4d) and mRNA levels of IL-1β, IL-6, and TNF-α were significantly decreased without hepatotoxicity. From the in vivo and in vitro test results, we confirmed that our synthesized compounds are effective for suppression of representative inflammatory cytokines. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | anti-inflammatory effect | * |
dc.subject | benzoxazole | * |
dc.subject | IL-1β | * |
dc.subject | IL-6 | * |
dc.subject | mRNA expression | * |
dc.subject | small molecules | * |
dc.subject | TNF-α | * |
dc.title | Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1β mRNA Expression | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | International Journal of Molecular Sciences | * |
dc.identifier.doi | 10.3390/ijms23105331 | * |
dc.identifier.wosid | WOS:000803503900001 | * |
dc.identifier.scopusid | 2-s2.0-85129709715 | * |
dc.author.google | Yoo J. | * |
dc.author.google | Park J. | * |
dc.author.google | Kim D. | * |
dc.author.google | Huh Y. | * |
dc.author.google | Choo H.-Y.P. | * |
dc.author.google | Woo H.A. | * |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.contributor.scopusid | 박지영(56144061400) | * |
dc.date.modifydate | 20240215164922 | * |