Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2022-06-02T16:32:15Z | - |
dc.date.available | 2022-06-02T16:32:15Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0144-8617 | * |
dc.identifier.other | OAK-31612 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261333 | - |
dc.description.abstract | Hyaluronic acid-graft-poly(propylene glycol) (HA-g-PPG) was prepared to induce hydrophobic interactions between HA-g-PPG and F127 PPGs (poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol)) and consequent increases in gel stability of F127 gel. Molecular weights of 340, 1000, and 2500 Da were used for PPG, and grafting ratios of HA-g-PPG varied over 3%, 12%, and 50%. Using rheology measurements, 1H NMR spectra, lower critical solution temperature measurements, dynamic light scattering, and transmission electron spectroscopy, hydrophobic crosslinking and intermicellar bridge formation were suggested in the aqueous HA-g-PPG/F127 hybrid solutions. In particular, the gel stability of the HA-g-PPG/F127 hybrid thermogel increased from 2 days (F127 only) to 6 days, thus the hybrid thermogel can provide longer delivery of an incorporated drug. The HA-g-PPG/F127 thermogel exhibited tissue compatibility in the subcutaneous layer of rats. The protein drug release from the gel indicated that interactions between negative charged HA-g-PPG and positive charged drug (calcitonin) reduced initial burst release. © 2022 | * |
dc.language | English | * |
dc.publisher | Elsevier Ltd | * |
dc.subject | Gel stability | * |
dc.subject | Hyaluronic acid | * |
dc.subject | Injectable | * |
dc.subject | Sustained drug release | * |
dc.subject | Thermogel | * |
dc.title | Hyaluronic acid-g-PPG and PEG-PPG-PEG hybrid thermogel for prolonged gel stability and sustained drug release | * |
dc.type | Article | * |
dc.relation.volume | 291 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Carbohydrate Polymers | * |
dc.identifier.doi | 10.1016/j.carbpol.2022.119559 | * |
dc.identifier.wosid | WOS:000806361900001 | * |
dc.identifier.scopusid | 2-s2.0-85130133326 | * |
dc.author.google | Kim S. | * |
dc.author.google | Lee H.J. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |