Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강상원 | * |
dc.contributor.author | 민성춘 | * |
dc.date.accessioned | 2022-06-02T16:31:23Z | - |
dc.date.available | 2022-06-02T16:31:23Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1016-8478 | * |
dc.identifier.other | OAK-31346 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261306 | - |
dc.description.abstract | Excessive production of reactive oxygen species (ROS) is a key phenomenon in tumor necrosis factor (TNF)-α-induced cell death. However, the role of ROS in necroptosis remains mostly elusive. In this study, we show that TNF-α induces the mitochondrial accumulation of superoxide anions, not H2O2, in cancer cells undergoing necroptosis. TNF-α-induced mitochondrial superoxide anions production is strictly RIP3 expression-dependent. Unexpectedly, TNF-α stimulates NADPH oxidase (NOX), not mitochondrial energy metabolism, to activate superoxide production in the RIP3-positive cancer cells. In parallel, mitochondrial superoxide-metabolizing enzymes, such as manganese-superoxide dismutase (SOD2) and peroxiredoxin III, are not involved in the superoxide accumulation. Mitochondrial-targeted superoxide scavengers and a NOX inhibitor eliminate the accumulated superoxide without affecting TNF-α-induced necroptosis. Therefore, our study provides the first evidence that mitochondrial superoxide accumulation is a consequence of necroptosis. © The Korean Society for Molecular and Cellular Biology. | * |
dc.language | English | * |
dc.publisher | Korean Society for Molecular and Cellular Biology | * |
dc.subject | NADPH oxidase | * |
dc.subject | necroptosis | * |
dc.subject | superoxide anion | * |
dc.subject | tumor necrosis factor-α | * |
dc.title | RIP3-Dependent Accumulation of Mitochondrial Superoxide Anions in TNF-α-Induced Necroptosis | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 45 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 193 | * |
dc.relation.lastpage | 201 | * |
dc.relation.journaltitle | Molecules and Cells | * |
dc.identifier.doi | 10.14348/molcells.2021.0260 | * |
dc.identifier.wosid | WOS:000771925600001 | * |
dc.identifier.scopusid | 2-s2.0-85127636402 | * |
dc.author.google | Lee J. | * |
dc.author.google | Lee S. | * |
dc.author.google | Min S. | * |
dc.author.google | Kang S.W. | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 민성춘(24171602800;57491085200) | * |
dc.date.modifydate | 20240527141040 | * |