Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2022-06-02T16:31:05Z | - |
dc.date.available | 2022-06-02T16:31:05Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.other | OAK-31459 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261204 | - |
dc.description.abstract | A new bicyclic macrolide, hamuramicin C (1), was isolated from Streptomyces sp. MBP16, a gut bacterial strain of the wasp Vespa crabro flavofasciata. Its 22-membered macrocyclic lactone structure was determined by NMR and mass spectrometry. The relative configurations of hamuramicin C (1) were assigned by J-based configuration analysis utilizing 1H rotating frame Overhauser effect spectroscopy and heteronuclear long-range coupling NMR spectroscopy. Genomic and bioinformatic analyses of the bacterial strain enabled identification of the type-I polyketide synthase pathway, which employs a trans-acyltransferase system. The absolute configurations of 1 were proposed based on the analysis of the sequences of ketoreductases in the modular gene cluster. Moreover, hamuramicin C (1) demonstrated significant inhibitory activity against diverse human cancer cell lines (HCT116, A549, SNU-638, SK-HEP-1, and MDA-MB-231). © 2022 American Chemical Society. All rights reserved. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.title | Hamuramicin C, a Cytotoxic Bicyclic Macrolide Isolated from a Wasp Gut Bacterium | * |
dc.type | Review | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 85 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 936 | * |
dc.relation.lastpage | 942 | * |
dc.relation.journaltitle | Journal of Natural Products | * |
dc.identifier.doi | 10.1021/acs.jnatprod.1c01075 | * |
dc.identifier.wosid | WOS:000791431400018 | * |
dc.identifier.scopusid | 2-s2.0-85128219766 | * |
dc.author.google | An J.S. | * |
dc.author.google | Lim H.-J. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Jang Y.-J. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Oh D.-C. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |