Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상혁 | * |
dc.contributor.author | 강상원 | * |
dc.contributor.author | 강동민 | * |
dc.contributor.author | 민성춘 | * |
dc.date.accessioned | 2022-03-31T16:32:31Z | - |
dc.date.available | 2022-03-31T16:32:31Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2213-2317 | * |
dc.identifier.other | OAK-31300 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261106 | - |
dc.description.abstract | Mitochondria communicate with other cellular compartments via the secretion of protein factors. Here, we report an unexpected messenger role for heat shock protein 60 (HSP60) as a mitochondrial-releasing protein factor that couples stress-sensing signaling and cell survival machineries. We show that mild oxidative stress predominantly activates the p38/MK2 complex, which phosphorylates mitochondrial fission factor 1 (MFF1) at the S155 site. Such phosphorylated MFF1 leads to the oligomerization of voltage anion-selective channel 1, thereby triggering the formation of a mitochondrial membrane pore through which the matrix protein HSP60 passes. The liberated HSP60 associates with and activates the IκB kinase (IKK) complex in the cytosol, which consequently induces the NF-κB-dependent expression of survival genes in nucleus. Indeed, inhibition of the HSP60 release or HSP60-IKK interaction sensitizes the cancer cells to mild oxidative stress and regresses the tumorigenic growth of cancer cells in the mouse xenograft model. Thus, this study reveals a novel mitonuclear survival axis responding to oxidative stress. © 2022 The Authors | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | HSP60 | * |
dc.subject | Mitochondria | * |
dc.subject | NF-κB | * |
dc.subject | Oxidative stress | * |
dc.subject | p38 MAPK | * |
dc.title | Heat shock protein 60 couples an oxidative stress-responsive p38/MK2 signaling and NF-κB survival machinery in cancer cells | * |
dc.type | Article | * |
dc.relation.volume | 51 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Redox Biology | * |
dc.identifier.doi | 10.1016/j.redox.2022.102293 | * |
dc.identifier.wosid | WOS:000792002200005 | * |
dc.identifier.scopusid | 2-s2.0-85126542460 | * |
dc.author.google | Min S. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Cho H.M. | * |
dc.author.google | Park S. | * |
dc.author.google | Hwang J.M. | * |
dc.author.google | You H. | * |
dc.author.google | Chan Chae Y. | * |
dc.author.google | Lee W.-J. | * |
dc.author.google | Sun W. | * |
dc.author.google | Kang D. | * |
dc.author.google | Lee S. | * |
dc.author.google | Kang S.W. | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 강동민(13103841000) | * |
dc.contributor.scopusid | 민성춘(24171602800;57491085200) | * |
dc.date.modifydate | 20240527141040 | * |