Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2022-03-31T16:31:27Z | - |
dc.date.available | 2022-03-31T16:31:27Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1567-5769 | * |
dc.identifier.other | OAK-31225 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261078 | - |
dc.description.abstract | Cystitis is a chronic bladder pain associated with frequency and nocturia. In the present study, Icariin a prenylated flavonoid extracted from Epimedium koreanum, was investigated against cyclophosphamide (CYP)-induced cystitis pain in mice model. Preliminarily in an acute model, single dose of CYP (150 mg/kg; i.p) was administered followed by Icariin (5, 25 and 50 mg/kg, i.p.). The visceral sensitivity and nociceptive behaviors were significantly ameliorated by pretreatment with Icariin (25, 50 mg/kg) that were assessed by spontaneous pain scoring, von Frey test and clinical scoring. Further, in chronic model Icariin (25 mg/kg, i.p.) was administered for 10 consecutive days prior to CYP (75 mg/kg; i.p) challenged every 3rd day for the duration of 10 days. Icariin not only had a protective effect on edema including bladder wet weight and hemorrhage but also had a potential to reduce vascular permeability, mast cells infiltration and tissue fibrosis. Evidently, Icariin prevented the neutrophilia/lymphopenia caused by CYP, and markedly improved the antioxidant enzymes level including superoxide dismutase, glutathione sulfo-transferase, catalase, glutathione level and reduced Malondialdehyde level, myeloperoxidase activity and nitric oxide, and also decreased the production of tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) in bladder. Icariin markedly enhanced the Nrf-2, heme oxygenase (HO-1) and IкB-α expression, while attenuated the expression level of Keap1, TLR-4, NF-кB, i-NOS, COX-2 and TRPV1 as compared to negative group. This research illustrated the anti-inflammatory properties of Icariin and effectively improved CYP-induced cystitis pain. © 2022 Elsevier B.V. | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | Cystitis pain | * |
dc.subject | Icariin | * |
dc.subject | Inflammation | * |
dc.subject | Oxidative stress and uro-protection | * |
dc.title | Icariin attenuates cyclophosphamide-induced cystitis via down-regulation of NF-кB and up-regulation of Nrf-2/HO-1 signaling pathways in mice model | * |
dc.type | Article | * |
dc.relation.volume | 106 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | International Immunopharmacology | * |
dc.identifier.doi | 10.1016/j.intimp.2022.108604 | * |
dc.identifier.wosid | WOS:000792893900005 | * |
dc.identifier.scopusid | 2-s2.0-85124282942 | * |
dc.author.google | Amanat S. | * |
dc.author.google | Shal B. | * |
dc.author.google | Kyoung Seo E. | * |
dc.author.google | Ali H. | * |
dc.author.google | Khan S. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |