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자연과학대학
화학·나노과학전공
Journal papers
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Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe
Title
Observing hepatic steatosis with a commercially viable two-photon fluorogenic probe
Authors
Han J.
;
Lee H.W.
;
Chen Y.
;
Li H.
;
Kim H.M.
;
Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영
Issue Date
2022
Journal Title
Materials Chemistry Frontiers
ISSN
2052-1537
Citation
Materials Chemistry Frontiers vol. 6, no. 5, pp. 553 - 560
Publisher
Royal Society of Chemistry
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
The key mechanism of lipid droplet-related diseases and polarity remains undetermined due to a scarcity of research on numerous condition models. We developed a conventional donor-acceptor fluorogenic probe with the untwisted intramolecular charge process. It is near-infrared-excited two-photon LD-specific and polarity-sensitive. This probe can detect dynamic changes of LD polarity in cancer cells and visualizes aberrant LD polarity in hepatic steatosis models. In the future, it could be beneficial for clinical diagnosis of LD polarity-related symptoms and to track the origin of lipid droplets and to monitor polarity-relative subcellular organelles. This journal is © the Partner Organisations.
DOI
10.1039/d1qm01665b
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