Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.contributor.author | 남상집 | * |
dc.contributor.author | K.M.K Swamy | * |
dc.date.accessioned | 2022-03-29T16:31:05Z | - |
dc.date.available | 2022-03-29T16:31:05Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1359-7345 | * |
dc.identifier.other | OAK-31106 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260954 | - |
dc.description.abstract | Glutathione (GSH) is known to play a key role in the modulation of the redox environment in N-methyl-d-aspartate (NMDA) receptors. Coumarin derivative 1 bearing cyanoacrylamide and ifenprodil moieties was synthesized and reported to monitor GSH near NMDA receptors. The cyanoacrylamide moiety allows probe 1 to monitor GSH reversibly at pH 7.4 and the ifenprodil group acts as a directing group for NMDA receptors. Two-photon fluorescence microscopy allows probe 1 to successfully sense endogenous GSH in neuronal cells and hippocampal tissues with excitation at 750 nm. Furthermore, the addition of H2O2 and GSH induced a decrease and an increase in fluorescence emission. Probe 1 can serve as a potential practical imaging tool to get important information on GSH in the brain. © 2022 The Royal Society of Chemistry. | * |
dc.language | English | * |
dc.publisher | Royal Society of Chemistry | * |
dc.title | A coumarin-based reversible two-photon fluorescence probe for imaging glutathione near N-methyl-d-aspartate (NMDA) receptors | * |
dc.type | Article | * |
dc.relation.issue | 22 | * |
dc.relation.volume | 58 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3633 | * |
dc.relation.lastpage | 3636 | * |
dc.relation.journaltitle | Chemical Communications | * |
dc.identifier.doi | 10.1039/d1cc05512g | * |
dc.identifier.wosid | WOS:000760404600001 | * |
dc.identifier.scopusid | 2-s2.0-85126831026 | * |
dc.author.google | Kwon N. | * |
dc.author.google | Lim C.S. | * |
dc.author.google | Lee D. | * |
dc.author.google | Ko G. | * |
dc.author.google | Ha J. | * |
dc.author.google | Cho M. | * |
dc.author.google | Swamy K.M.K. | * |
dc.author.google | Lee E.-Y. | * |
dc.author.google | Lee D.J. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Zhou X. | * |
dc.author.google | Kim H.M. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.contributor.scopusid | K.M.K Swamy(8384468700) | * |
dc.date.modifydate | 20240220120010 | * |