Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송은주 | * |
dc.date.accessioned | 2022-03-29T16:31:03Z | - |
dc.date.available | 2022-03-29T16:31:03Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2072-6694 | * |
dc.identifier.other | OAK-31116 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260944 | - |
dc.description.abstract | MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate a countless number of genes in the cell, and the aberrant expression of miRNA can lead to cancer. Here, we demonstrate that miR-101-3p regulates the RPL11–MDM2–p53 pathway by targeting ubiquitin-specific peptidase 47 (USP47), consequently inhibiting cancer cell proliferation. We confirm that miR-101-3p directly binds to the 3′-UTR region of the USP47 gene and inhibits USP47 expression. In addition, the overexpression of miR-101-3p suppresses cell proliferation in a p53-dependent manner. MiR-101-3p promotes interaction between RPL11 and MDM2 by inducing the translocation of RPL11 from the nucleolus to the nucleoplasm, thus preventing the MDM2-mediated proteasomal degradation of p53. However, these phenomena are restored by the overexpression of USP47, but not by its catalytically inactive form. Indeed, miR-101-3p regulates RPL11 localization and its interaction with MDM2 by inhibiting the USP47-induced deubiquitination of RPL11. Finally, the expression of miR-101-3p is downregulated in lung cancer patients, and the patients with low miR-101-3p expression exhibit a lower survival rate, indicating that miR-101-3p is associated with tumorigenesis. Together, our findings suggest that miR-101-3p functions as a tumor suppressor by targeting USP47 and could be a potential therapeutic target for cancers. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | Cancer cell growth | * |
dc.subject | MiR-101-3p | * |
dc.subject | P53 | * |
dc.subject | RPL11 | * |
dc.subject | USP47 | * |
dc.title | MicroRNA-101-3p Suppresses Cancer Cell Growth by Inhibiting the USP47-Induced Deubiquitination of RPL11 | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Cancers | * |
dc.identifier.doi | 10.3390/cancers14040964 | * |
dc.identifier.wosid | WOS:000761415600001 | * |
dc.identifier.scopusid | 2-s2.0-85124458324 | * |
dc.author.google | Park J. | * |
dc.author.google | Cho M. | * |
dc.author.google | Cho J. | * |
dc.author.google | Kim E.E. | * |
dc.author.google | Song E.J. | * |
dc.contributor.scopusid | 송은주(7101904210) | * |
dc.date.modifydate | 20240311110828 | * |