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Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.
- Title
- Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.
- Authors
- Kim S.; Le T.C.; Han S.-A.; Hillman P.F.; Hong A.; Hwang S.; Du Y.E.; Kim H.; Oh D.-C.; Cha S.-S.; Lee J.; Nam S.-J.; Fenical W.
- Ewha Authors
- 남상집; 차선신
- SCOPUS Author ID
- 남상집; 차선신
- Issue Date
- 2022
- Journal Title
- Marine Drugs
- ISSN
- 1660-3397
- Citation
- Marine Drugs vol. 20, no. 1
- Keywords
- Antibacterial activity; Marine natural products; Saccharomonospora sp
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/md20010035
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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