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Pediatric-inspired regimen with late intensifi- cation and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
- Title
- Pediatric-inspired regimen with late intensifi- cation and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study
- Authors
- Baek, Dong Won; Kim, Dae Young; Sohn, Sang Kyun; Koh, Youngil; Jung, Sung-Hoon; Yhim, Ho-Young; Choi, Yunsuk; Moon, Joon Ho
- Ewha Authors
- 김대영
- SCOPUS Author ID
- 김대영
- Issue Date
- 2021
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- ISSN
- 1226-3303
2005-6648
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE vol. 36, no. 6, pp. 1471 - +
- Keywords
- Precursor cell lymphoblastic leukemia-lymphoma; Drug therapy; As-paraginase; Stem cell transplantation
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Indexed
- SCIE; KCI
- Document Type
- Article
- Abstract
- Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology. Methods: Data of 99 patients with newly diagnosed ALL, who were treated with the KALLA 1406/1407 protocol, were retrospectively analyzed. All patients equally received age-adjusted daunorubicin, vincristine, and prednisolone. L-asparaginase was additionally administered to Philadelphia (Ph)-negative patients according to age, whereas Ph-positive patients received 600 mg/day of imatinib. Results: A total of 99 patients were enrolled in this study, of whom 62 (62.6%) were diagnosed with Ph-negative ALL and 37 (37.3%) were diagnosed with Ph -positive ALL. The median age of patients in the Ph-negative ALL group was 46 years, and that of patients in the Ph-positive ALL group was 49 years. In patients with Ph-negative ALL, 57 (92%) patients achieved complete remission (CR) and CR with incomplete hematologic recovery (CRi). Disease-free survival (DFS) and overall survival (OS) rates at 2 years were estimated to be 42% and 63%, respectively. In patients with Ph-positive ALL, 32 (86%) patients achieved CR/CRi, and 2-year DFS and OS were 31.2% and 49.1%, respectively. Patients who were able to proceed to the allogeneic hematopoietic cell transplantation and younger patients showed significantly superior survival in both Ph-negative ALL and Ph-positive ALL. Neutropenic fever and bacterial infection were the most common and severe adverse events. Conclusions: The KALLA 1406/1407 protocol showed tolerable toxicities in adult ALL patients. Especially, younger patients had more survival benefits with KALLA 1406/1407 protocol.
- DOI
- 10.3904/kjim.2021.028
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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