Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김대영 | - |
dc.date.accessioned | 2022-02-14T16:31:03Z | - |
dc.date.available | 2022-02-14T16:31:03Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.other | OAK-30987 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260464 | - |
dc.description.abstract | Background/Aims: The objective of this study was to evaluate the efficacy and feasibility of the pediatric-inspired regimen of the adult acute lymphoblastic leukemia (ALL) Working Party, the Korean Society of Hematology. Methods: Data of 99 patients with newly diagnosed ALL, who were treated with the KALLA 1406/1407 protocol, were retrospectively analyzed. All patients equally received age-adjusted daunorubicin, vincristine, and prednisolone. L-asparaginase was additionally administered to Philadelphia (Ph)-negative patients according to age, whereas Ph-positive patients received 600 mg/day of imatinib. Results: A total of 99 patients were enrolled in this study, of whom 62 (62.6%) were diagnosed with Ph-negative ALL and 37 (37.3%) were diagnosed with Ph -positive ALL. The median age of patients in the Ph-negative ALL group was 46 years, and that of patients in the Ph-positive ALL group was 49 years. In patients with Ph-negative ALL, 57 (92%) patients achieved complete remission (CR) and CR with incomplete hematologic recovery (CRi). Disease-free survival (DFS) and overall survival (OS) rates at 2 years were estimated to be 42% and 63%, respectively. In patients with Ph-positive ALL, 32 (86%) patients achieved CR/CRi, and 2-year DFS and OS were 31.2% and 49.1%, respectively. Patients who were able to proceed to the allogeneic hematopoietic cell transplantation and younger patients showed significantly superior survival in both Ph-negative ALL and Ph-positive ALL. Neutropenic fever and bacterial infection were the most common and severe adverse events. Conclusions: The KALLA 1406/1407 protocol showed tolerable toxicities in adult ALL patients. Especially, younger patients had more survival benefits with KALLA 1406/1407 protocol. | - |
dc.language | English | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | Precursor cell lymphoblastic leukemia-lymphoma | - |
dc.subject | Drug therapy | - |
dc.subject | As-paraginase | - |
dc.subject | Stem cell transplantation | - |
dc.title | Pediatric-inspired regimen with late intensifi- cation and increased dose of L-asparaginase for adult acute lymphoblastic leukemia: the KALLA 1406/1407 study | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 36 | - |
dc.relation.index | SCIE | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 1471 | - |
dc.relation.lastpage | + | - |
dc.relation.journaltitle | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.identifier.doi | 10.3904/kjim.2021.028 | - |
dc.identifier.wosid | WOS:000723847800002 | - |
dc.author.google | Baek, Dong Won | - |
dc.author.google | Kim, Dae Young | - |
dc.author.google | Sohn, Sang Kyun | - |
dc.author.google | Koh, Youngil | - |
dc.author.google | Jung, Sung-Hoon | - |
dc.author.google | Yhim, Ho-Young | - |
dc.author.google | Choi, Yunsuk | - |
dc.author.google | Moon, Joon Ho | - |
dc.contributor.scopusid | 김대영(57223374431;57366548100) | - |
dc.date.modifydate | 20230208102836 | - |