Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2022-02-14T16:31:03Z | - |
dc.date.available | 2022-02-14T16:31:03Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-30993 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260458 | - |
dc.description.abstract | An ubiquinone derivative, pseudoalteromone A (1), has been isolated from two marine-derived Pseudoalteromonas spp., APmarine002 and ROA-050, and its anti-melanogenesis activity was investigated. The anti-melanogenic capacity of pseudoalteromone A was demonstrated by assessing the intracellular and extracellular melanin content and cellular tyrosinase activity in the B16 cell line, Melan-a mouse melanocyte cell line, and MNT-1 human malignant melanoma cell line. Treatment with pseudoalteromone A (40 mu g/mL) for 72 h reduced alpha-melanocyte-stimulating hormone (alpha-MSH)-induced intracellular melanin production by up to 44.68% in B16 cells and 38.24% in MNT-1 cells. Notably, pseudoalteromone A induced a concentration-dependent reduction in cellular tyrosinase activity in B16 cell, and Western blot analyses showed that this inhibitory activity was associated with a significant decrease in protein levels of tyrosinase and tyrosinase-related protein 1 (Tyrp-1), suggesting that pseudoalteromone A exerts its anti-melanogenesis activity through effects on melanogenic genes. We further evaluated the skin-whitening effect of pseudoalteromone A in the three-dimensional (3D) pigmented-epidermis model, MelanoDerm, and visualized the 3D distribution of melanin by two-photon excited fluorescence imaging in this human skin equivalent. Collectively, our findings suggest that pseudoalteromone A inhibits tyrosinase activity and expression and that this accounts for its anti-melanogenic effects in melanocytes. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | <p>Pseudoalteromonas sp.</p> | * |
dc.subject | pseudoalteromone A | * |
dc.subject | marine natural product | * |
dc.subject | melanogenesis | * |
dc.title | Pseudoalteromone A, a Ubiquinone Derivative from Marine Pseudoalteromonas spp., Suppresses Melanogenesis | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MARINE DRUGS | * |
dc.identifier.doi | 10.3390/md19110612 | * |
dc.identifier.wosid | WOS:000724959200001 | * |
dc.author.google | Lim, Su-Jin | * |
dc.author.google | Min, Dae-Jin | * |
dc.author.google | Kim, Sohee | * |
dc.author.google | Lee, Jihye | * |
dc.author.google | Lee, Eun-Soo | * |
dc.author.google | Kim, Hyuk | * |
dc.author.google | Cho, Sung-Yoen | * |
dc.author.google | Beak, Heung-Soo | * |
dc.author.google | Lee, Chang-Seok | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Ko, Jaeyoung | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |