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Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
- Title
- Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
- Authors
- Zahan Md.S.; Ahmed K.A.; Moni A.; Sinopoli A.; Ha H.; Uddin M.J.
- Ewha Authors
- 하헌주; Md Jamal Uddin
- SCOPUS Author ID
- 하헌주; Md Jamal Uddin
- Issue Date
- 2022
- Journal Title
- Korean Journal of Physiology and Pharmacology
- ISSN
- 1226-4512
- Citation
- Korean Journal of Physiology and Pharmacology vol. 26, no. 1, pp. 1 - 13
- Publisher
- Korean Physiological Soc. and Korean Soc. of Pharmacology
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various pathophysiological conditions in various disease models. LF shows protective effects against AKI and CKD. LF reduces markers related to inflammation, oxidative stress, apoptosis, and kidney fibrosis, and induces autophagy and mitochondrial biogenesis in the kidney. Although there are no clinical trials of LF to treat kidney disease, several clinical trials and studies on LF-based drug development are ongoing. In this review, we discussed the possible kidney protective mechanisms of LF, as well as the pharmacological and therapeutic advances. The evidence suggests that LF may become a potent pharmacological agent to treat kidney diseases. © 2022 Korean Physiological Soc. and Korean Soc. of Pharmacology. All rights reserved.
- DOI
- 10.4196/kjpp.2022.26.1.1
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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