View : 359 Download: 0
Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits
- Title
- Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits
- Authors
- Choi, Juli; Kwon, Hye-Jin; Seoh, Ju-Young; Han, Pyung-Lim
- Ewha Authors
- 서주영; 한평림
- SCOPUS Author ID
- 서주영; 한평림
- Issue Date
- 2021
- Journal Title
- EXPERIMENTAL NEUROBIOLOGY
- ISSN
- 1226-2560
2093-8144
- Citation
- EXPERIMENTAL NEUROBIOLOGY vol. 30, no. 6, pp. 415 - 429
- Keywords
- Hyperoxygenation; Chronic stress; Mitochondria; Neurogenesis
- Publisher
- KOREAN SOC BRAIN &
NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Hyperoxygenation therapy remediates neuronal injury and improves cognitive function in various animal models. In the present study, the optimal conditions for hyperoxygenation treatment of stress-induced maladaptive changes were investigated. Mice exposed to chronic restraint stress (CRST) produce persistent adaptive changes in genomic responses and exhibit depressive-like behaviors. Hyperoxygenation treatment with 100% O-2 (HO2) at 2.0 atmospheres absolute (ATA) for 1 h daily for 14 days in CRST mice produces an antidepressive effect similar to that of the antidepressant imipramine. In contrast, HO2 treatment at 2.0 ATA for 1 h daily for shorter duration (3, 5, or 7 days), HO2 treatment at 1.5 ATA for 1 h daily for 14 days, or hyperbaric air treatment at 2.0 ATA (42% O-2) for 1 h daily for 14 days is ineffective or less effective, indicating that repeated sufficient hyperoxygenation conditions are required to reverse stress-induced maladaptive changes. HO2 treatment at 2.0 ATA for 14 days restores stress-induced reductions in levels of mitochondrial copy number, stress-induced attenuation of synaptophysin-stained density of axon terminals and MAP-2-staining dendritic processes of pyramidal neurons in the hippocampus, and stress-induced reduced hippocampal neurogenesis. These results suggest that HO2 treatment at 2.0 ATA for 14 days is effective to ameliorate stress-induced neuronal and behavioral deficits.
- DOI
- 10.5607/en21029
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML