Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서주영 | - |
dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2022-02-14T16:30:58Z | - |
dc.date.available | 2022-02-14T16:30:58Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.other | OAK-31027 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260426 | - |
dc.description.abstract | Hyperoxygenation therapy remediates neuronal injury and improves cognitive function in various animal models. In the present study, the optimal conditions for hyperoxygenation treatment of stress-induced maladaptive changes were investigated. Mice exposed to chronic restraint stress (CRST) produce persistent adaptive changes in genomic responses and exhibit depressive-like behaviors. Hyperoxygenation treatment with 100% O-2 (HO2) at 2.0 atmospheres absolute (ATA) for 1 h daily for 14 days in CRST mice produces an antidepressive effect similar to that of the antidepressant imipramine. In contrast, HO2 treatment at 2.0 ATA for 1 h daily for shorter duration (3, 5, or 7 days), HO2 treatment at 1.5 ATA for 1 h daily for 14 days, or hyperbaric air treatment at 2.0 ATA (42% O-2) for 1 h daily for 14 days is ineffective or less effective, indicating that repeated sufficient hyperoxygenation conditions are required to reverse stress-induced maladaptive changes. HO2 treatment at 2.0 ATA for 14 days restores stress-induced reductions in levels of mitochondrial copy number, stress-induced attenuation of synaptophysin-stained density of axon terminals and MAP-2-staining dendritic processes of pyramidal neurons in the hippocampus, and stress-induced reduced hippocampal neurogenesis. These results suggest that HO2 treatment at 2.0 ATA for 14 days is effective to ameliorate stress-induced neuronal and behavioral deficits. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC BRAIN & | - |
dc.publisher | NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE | - |
dc.subject | Hyperoxygenation | - |
dc.subject | Chronic stress | - |
dc.subject | Mitochondria | - |
dc.subject | Neurogenesis | - |
dc.title | Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 415 | - |
dc.relation.lastpage | 429 | - |
dc.relation.journaltitle | EXPERIMENTAL NEUROBIOLOGY | - |
dc.identifier.doi | 10.5607/en21029 | - |
dc.identifier.wosid | WOS:000740942100004 | - |
dc.author.google | Choi, Juli | - |
dc.author.google | Kwon, Hye-Jin | - |
dc.author.google | Seoh, Ju-Young | - |
dc.author.google | Han, Pyung-Lim | - |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |