Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2021-11-16T16:31:48Z | - |
dc.date.available | 2021-11-16T16:31:48Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0143-7208 | * |
dc.identifier.issn | 1873-3743 | * |
dc.identifier.other | OAK-30149 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259528 | - |
dc.description.abstract | Peroxynitrite (ONOO-), a reactive nitrogen species (RNS), engages in various cellular processes including inflammation, apoptosis, and necrosis. Therefore, the development of a powerful tool for imaging endogenous ONOO- is important with regard to revealing its underlying physiological or pathological functions. In this work, we introduced dihalogen (Cl, Br, and I) at the ortho-positions of the hydroxyl group of a dicyanoisophorone skeleton to adjust its pKa to be more suitable for bio-imaging in the physiological environments with a high signal-to-noise ratio. Based on the optimized spectral results and the requirement of biocompatibility, the fluorescent probe NIR-dCl was successfully designed and fabricated for the detection of ONOO-. Upon the addition of ONOO- in solution, an obvious NIR fluorescent signal at 680 nm was observed. Moreover, the probe NIR-dCl exhibited high selectivity for sensing ONOO-. Cell imaging results confirmed that probe NIR-dCl was capable of imaging exogenous and endogenous ONOO- in live cells. Thus, we believe that probe NIR-dCl could be an effective tool for studying biochemical processes and ONOO--related diseases. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCI LTD | * |
dc.subject | Reactive nitrogen species | * |
dc.subject | pKa regulation | * |
dc.subject | Cell imaging | * |
dc.subject | NIR Fluorescent probe | * |
dc.title | Reasonably constructed NIR fluorescent probes based on dicyanoisophorone skeleton for imaging ONOO- in living cells | * |
dc.type | Article | * |
dc.relation.volume | 195 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | DYES AND PIGMENTS | * |
dc.identifier.doi | 10.1016/j.dyepig.2021.109665 | * |
dc.identifier.wosid | WOS:000693246200003 | * |
dc.identifier.scopusid | 2-s2.0-85111641736 | * |
dc.author.google | Chung, Jeewon | * |
dc.author.google | Kim, Heejeong | * |
dc.author.google | Li, Haidong | * |
dc.author.google | Yoon, Juyoung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |