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The core composition of DNA block copolymer micelles dictates DNA hybridization properties, nuclease stabilities, and cellular uptake efficiencies
- Title
- The core composition of DNA block copolymer micelles dictates DNA hybridization properties, nuclease stabilities, and cellular uptake efficiencies
- Authors
- Kim, Chan-Jin; Kim, Ga-Hyun; Jeong, Eun Hye; Lee, Hyukjin; Park, So-Jung
- Ewha Authors
- 이혁진; 박소정; 김찬진; 정은혜
- SCOPUS Author ID
- 이혁진; 박소정; 김찬진; 정은혜
- Issue Date
- 2021
- Journal Title
- NANOSCALE
- ISSN
- 2040-3364
2040-3372
- Citation
- NANOSCALE vol. 13, no. 32, pp. 13758 - 13763
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Here, we report how the nature of the hydrophobic core affects the molecular interactions of DNA block copolymer assemblies. Three different amphiphilic DNA block copolymers, DNA-b-polystyrene (DNA-b-PS), DNA-b-poly(2-vinylpyridine) (DNA-b-P2VP), and DNA-b-poly(methyl acrylate) (DNA-b-PMA) were synthesized and assembled into spherical micelles composed of a hydrophobic polymer core and DNA corona. Interestingly, DNA block copolymer micelles having different hydrophobic cores exhibited markedly different molecular and biological interactions. DNA-b-PS exhibited higher melting temperature, sharper melting transition, higher stability to nuclease-catalyzed DNA degradation, and higher cellular uptake efficiency compared to DNA-b-P2VP and DNA-b-PMA. The investigation of the self-assembly behavior revealed a much higher aggregation number and DNA density for DNA-b-PS micelles, which explains the superior properties of DNA-b-PS. These results demonstrate that the type of the hydrophobic core polymer, which has been largely overlooked, has a profound impact on the molecular and biological interactions of the DNA shell.
- DOI
- 10.1039/d1nr00756d
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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