Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2021-11-10T16:31:05Z | - |
dc.date.available | 2021-11-10T16:31:05Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0003-2700 | * |
dc.identifier.issn | 1520-6882 | * |
dc.identifier.other | OAK-30125 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259318 | - |
dc.description.abstract | N-Methyl-D-aspartate (NMDA) is an excitotoxic amino acid used to identify a specific subset of glutamate receptors. The activity of NMDA receptors is closely related to the redox level of the biological system. Glutathione (GSH) as an antioxidant plays a key role with regard to modulation of the redox environment. In this work we designed and developed a GSH-specific fluorescent probe with the capability of targeting NMDA receptors, which was composed of a two-photon naphthalimide fluorophore, a GSHreactive group sulfonamide, and an ifenprodil targeting group for the NMDA receptor. This probe exhibited high selectivity toward GSH in comparison to other similar amino acids. Two-photon fluorescence microscopy allowed this probe to successfully monitor GSH in neuronal cells and hippocampal tissues with an excitation at 750 nm. It could serve as a potential practical imaging tool to explore the function of GSH and related biological processes in the brain. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Fluorescence Probe for Imaging N-Methyl-D-aspartate Receptors and Monitoring GSH Selectively Using Two-Photon Microscopy | * |
dc.type | Article | * |
dc.relation.issue | 33 | * |
dc.relation.volume | 93 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 11612 | * |
dc.relation.lastpage | 11616 | * |
dc.relation.journaltitle | ANALYTICAL CHEMISTRY | * |
dc.identifier.doi | 10.1021/acs.analchem.1c02350 | * |
dc.identifier.wosid | WOS:000691297400031 | * |
dc.author.google | Kwon, Nahyun | * |
dc.author.google | Lim, Chang Su | * |
dc.author.google | Ko, Gyeongju | * |
dc.author.google | Ha, Jeongsun | * |
dc.author.google | Lee, Dayoung | * |
dc.author.google | Yin, Jun | * |
dc.author.google | Kim, Hwan Myung | * |
dc.author.google | Yoon, Juyoung | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |