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Access to the Triplet Excited States of Heavy-Atom-Free Boron-Dipyrromethene Photosensitizers via Radical Pair Intersystem Crossing for Image-Guided Tumor-Targeted Photodynamic Therapy
- Title
- Access to the Triplet Excited States of Heavy-Atom-Free Boron-Dipyrromethene Photosensitizers via Radical Pair Intersystem Crossing for Image-Guided Tumor-Targeted Photodynamic Therapy
- Authors
- Van-Nghia Nguyen; Ha, Jeongsun; Koh, Chang Woo; Ryu, Bokyeong; Kim, Gyoungmi; Park, Jae Hak; Kim, C-Yoon; Park, Sungnam; Yoon, Juyoung
- Ewha Authors
- 윤주영; Nguyen Van Nghia
- SCOPUS Author ID
- 윤주영
; Nguyen Van Nghia![scopus](/images/layout/icon2.png)
- Issue Date
- 2021
- Journal Title
- CHEMISTRY OF MATERIALS
- ISSN
- 0897-4756
1520-5002
- Citation
- CHEMISTRY OF MATERIALS vol. 33, no. 19, pp. 7889 - 7896
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Boron- dipyrromethene (BODIPY) dyes have aroused considerable interest in cancer theranostics over the past decade because of robust photochemical properties. Although a large number of BODIPY photosensitizers (PSs) containing heavy atoms have been reported, the development of heavy-atom-free BODIPY PSs for oncologic photodynamic therapy (PDT) has been limited mainly by the uncertainty in intersystem crossing (ISC) mechanisms, unbalanced phototoxic effectiveness and fluorescence quantum yields, and aggregation-caused quenching effects. In addition, the lack of extensive in vivo studies of heavyatom-free BODIPY PSs continues to limit clinical application. Herein, novel heavy-atom-free BODIPY-phenoxazine triads (BDP-8/BDP-9) that generate efficient excited triplet states via radical pair intersystem crossing (RP-ISC) followed by triplet charge recombination were developed for use in fluorescence image-guided PDT. BDP-8/BDP-9 exhibited high molar absorption coefficients, prominent aggregation-induced emission, and excellent singlet oxygen generation capability upon light irradiation. The corresponding BODIPY nanoparticles (BDP-8/BDP-9 NPs) with bright red emission, considerable phototoxicity, and excellent tumor-targeting ability were simply prepared by encapsulating BDP-8/BDP-9 PSs in a polymeric matrix. More importantly, the results of both in vitro and in vivo experiments demonstrated the considerable potential of BDP-8 NPs for image-guided photodynamic cancer therapy. This study may inspire the development of potential BODIPY-based nanoagents for cancer theranostics.
- DOI
- 10.1021/acs.chemmater.1c02776
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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