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Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
- Title
- Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
- Authors
- Kim, Hong Kwan; Joung, Je-Gun; Choi, Yoon-La; Lee, Se-Hoon; Park, Byung Jo; Choi, Yong Soo; Ryu, Daeun; Nam, Jae-Yong; Lee, Mi-Sook; Park, Woong-Yang; Hwang, Soohyun; Cha, Hongui; Kim, Hong Sook; Lee, Sanghyuk; Jung, Yeonjoo; Lee, Jong Eun; Doh, Junsang; Paik, Soonmyung; Kang, Jung Hee; Lee, Jinseon; Kim, Jhingook
- Ewha Authors
- 이상혁; 정연주
- SCOPUS Author ID
- 이상혁
; 정연주![scopus](/images/layout/icon2.png)
- Issue Date
- 2020
- Journal Title
- ISCIENCE
- ISSN
- 2589-0042
- Citation
- ISCIENCE vol. 23, no. 8
- Publisher
- CELL PRESS
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Exome and transcriptome analyses of clinically homogeneous early-stage never -smoker female patients with lung adenocarcinoma were performed to under-stand tumor-T cell interactions and immune escape points. Using our novel gene panels of eight functional categories in the cancer-immunity cycle, three distinct subgroups were identified in this immune checkpoint blockade-refractory cohort by defective gene expression in two major domains, i.e., type I interferon production/signaling pathway and antigen-presenting machinery. Our approach could play a critical role in understanding immune evasion mechanisms, devel-oping a method for effective selection of rare immune checkpoint blockade re-sponders, and finding new treatment strategies.
- DOI
- 10.1016/j.isci.2020.101386
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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