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A radiomic signature model to predict the chemoradiation-induced alteration in tumor-infiltrating CD8(+) cells in locally advanced rectal cancer
- Title
- A radiomic signature model to predict the chemoradiation-induced alteration in tumor-infiltrating CD8(+) cells in locally advanced rectal cancer
- Authors
- Jeon, Seung Hyuck; Lim, Yu Jin; Koh, Jaemoon; Chang, Won Ick; Kim, Sehui; Kim, Kyubo; Chie, Eui Kyu
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2021
- Journal Title
- RADIOTHERAPY AND ONCOLOGY
- ISSN
- 0167-8140
1879-0887
- Citation
- RADIOTHERAPY AND ONCOLOGY vol. 162, pp. 124 - 131
- Keywords
- Rectal neoplasms; Radiomics; CD8-positive T-lymphocytes; Chemoradiotherapy; Radiomic score; Neoadjuvant therapy
- Publisher
- ELSEVIER IRELAND LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and purpose: Regarding the altered tumor immune status following cytotoxic treatment, this study aims to develop a radiomic signature to predict CD8(+) tumor-infiltrating lymphocyte (TIL) density changes in chemoradiotherapy (CRT) of rectal cancer. Materials and methods: We used the magnetic resonance imaging (MRI) and immunohistochemistry data before and after neoadjuvant CRT. The discovery datasets consisted of pre-CRT dataset A1 (n = 113), post-CRT datasets A2 (n = 32; predominance of tumor) and A3 (n = 20; pure fibrosis). The developed model was validated in dataset B (n = 28). Thirty-eight radiomic features from T2-weighted MRI scans were incorporated into the least absolute shrinkage and selection operator method. Results: In pre-CRT dataset A1, the area under the receiver operating characteristic curve (AUC) values of radiomic score for predicting CD8(+) TILs were 0.760 and 0.729 for training and validation subsets, respectively. A significant correlation was observed between the signature and CD8(+) TIL density in the post-CRT dataset A2 (Pearson's R = -0.372, P = 0.036), whereas no association was found in dataset A3 (Pearson's R = -0.069, P = 0.77). The association was also observed in the validation dataset B (Pearson's R = -0.374, P = 0.049). In dataset A2, the radiomic score difference predicted changes in CD8(+) TIL density (AUC = 0.824). Conclusion: We established the MRI-derived radiomic signature for predicting CRT-induced alterations in CD8(+) TILs. This study suggests the clinical utility of radiomics-immunophenotype modeling to evaluate tumor immune status following neoadjuvant chemoradiation in rectal cancer. (C) 2021 Elsevier B.V. All rights reserved.
- DOI
- 10.1016/j.radonc.2021.07.004
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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