Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2021-08-12T16:32:27Z | - |
dc.date.available | 2021-08-12T16:32:27Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0167-8140 | * |
dc.identifier.issn | 1879-0887 | * |
dc.identifier.other | OAK-29861 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258806 | - |
dc.description.abstract | Background and purpose: Regarding the altered tumor immune status following cytotoxic treatment, this study aims to develop a radiomic signature to predict CD8(+) tumor-infiltrating lymphocyte (TIL) density changes in chemoradiotherapy (CRT) of rectal cancer. Materials and methods: We used the magnetic resonance imaging (MRI) and immunohistochemistry data before and after neoadjuvant CRT. The discovery datasets consisted of pre-CRT dataset A1 (n = 113), post-CRT datasets A2 (n = 32; predominance of tumor) and A3 (n = 20; pure fibrosis). The developed model was validated in dataset B (n = 28). Thirty-eight radiomic features from T2-weighted MRI scans were incorporated into the least absolute shrinkage and selection operator method. Results: In pre-CRT dataset A1, the area under the receiver operating characteristic curve (AUC) values of radiomic score for predicting CD8(+) TILs were 0.760 and 0.729 for training and validation subsets, respectively. A significant correlation was observed between the signature and CD8(+) TIL density in the post-CRT dataset A2 (Pearson's R = -0.372, P = 0.036), whereas no association was found in dataset A3 (Pearson's R = -0.069, P = 0.77). The association was also observed in the validation dataset B (Pearson's R = -0.374, P = 0.049). In dataset A2, the radiomic score difference predicted changes in CD8(+) TIL density (AUC = 0.824). Conclusion: We established the MRI-derived radiomic signature for predicting CRT-induced alterations in CD8(+) TILs. This study suggests the clinical utility of radiomics-immunophenotype modeling to evaluate tumor immune status following neoadjuvant chemoradiation in rectal cancer. (C) 2021 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER IRELAND LTD | * |
dc.subject | Rectal neoplasms | * |
dc.subject | Radiomics | * |
dc.subject | CD8-positive T-lymphocytes | * |
dc.subject | Chemoradiotherapy | * |
dc.subject | Radiomic score | * |
dc.subject | Neoadjuvant therapy | * |
dc.title | A radiomic signature model to predict the chemoradiation-induced alteration in tumor-infiltrating CD8(+) cells in locally advanced rectal cancer | * |
dc.type | Article | * |
dc.relation.volume | 162 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 124 | * |
dc.relation.lastpage | 131 | * |
dc.relation.journaltitle | RADIOTHERAPY AND ONCOLOGY | * |
dc.identifier.doi | 10.1016/j.radonc.2021.07.004 | * |
dc.identifier.wosid | WOS:000704336600017 | * |
dc.identifier.scopusid | 2-s2.0-85111068366 | * |
dc.author.google | Jeon, Seung Hyuck | * |
dc.author.google | Lim, Yu Jin | * |
dc.author.google | Koh, Jaemoon | * |
dc.author.google | Chang, Won Ick | * |
dc.author.google | Kim, Sehui | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Chie, Eui Kyu | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |