Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2021-08-12T16:31:12Z | - |
dc.date.available | 2021-08-12T16:31:12Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1017-7825 | * |
dc.identifier.issn | 1738-8872 | * |
dc.identifier.other | OAK-29883 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258650 | - |
dc.description.abstract | Three compounds were isolated from marine-derived Streptomyces sp. CNQ-031, and their inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase (BACE-1) were evaluated. Compound 1 (5,7-dihydroxy-2-isopropyl-4H-chromen-4-one) was a potent and selective inhibitor of MAO-A, with a 50% inhibitory concentration (IC50) of 2.70 mu M and a selectivity index (SI) of 10.0 versus MAO-B. Compound 2 [5,7-dihydroxy-2-(1-methylpropyl)-4H-chromen-4-one] was a potent and low-selective inhibitor of MAO-B, with an IC50 of 3.42 mu M and an SI value of 2.02 versus MAO-A. Compound 3 (1-methoxyphenazine) did not inhibit MAO-A or MAO-B. All three compounds showed little inhibitory activity against AChE, BChE, and BACE-1. The K-i value of compound 1 for MAO-A was 0.94 +/- 0.28 mu M, and the K-i values of compound 2 for MAO-A and MAO-B were 3.57 +/- 0.60 and 1.89 +/- 0.014 mu M, respectively, with competitive inhibition. The 1-methylpropyl group in compound 2 increased the MAO-B inhibitory activity compared with the isopropyl group in compound 1. Inhibition of MAO-A and MAO-B by compounds 1 and 2 was recovered by dialysis experiments. These results suggest that compounds 1 and 2 are reversible, competitive inhibitors of MAOs and can be considered potential therapies for neurological disorders such as depression and Alzheimer's disease. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC MICROBIOLOGY & | * |
dc.publisher | BIOTECHNOLOGY | * |
dc.subject | Monoamine oxidases | * |
dc.subject | chromenone derivatives | * |
dc.subject | Streptomyces sp | * |
dc.subject | CNQ-031 | * |
dc.subject | reversible competitive inhibitors | * |
dc.title | Chromenone Derivatives as Monoamine Oxidase Inhibitors from Marine-Derived MAR4 Clade Streptomyces sp. CNQ-031 | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1022 | * |
dc.relation.lastpage | 1027 | * |
dc.relation.journaltitle | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | * |
dc.identifier.doi | 10.4014/jmb.2105.05003 | * |
dc.identifier.wosid | WOS:000678421900013 | * |
dc.author.google | Oh, Jong Min | * |
dc.author.google | Lee, Chaeyoung | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Kim, Hoon | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |