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Disulfiram Treatment Normalizes Body Weight in Obese Mice
- Title
- Disulfiram Treatment Normalizes Body Weight in Obese Mice
- Authors
- Bernier, Michel; Mitchell, Sarah J.; Wahl, Devin; Diaz, Antonio; Singh, Abhishek; Seo, Wonhyo; Wang, Mingy; Ali, Ahmed; Kaiser, Tamzin; Price, Nathan L.; Aon, Miguel A.; Kim, Eun-Young; Petr, Michael A.; Cai, Huan; Warren, Alessa; Di Germanio, Clara; Di Francesco, Andrea; Fishbein, Ken; Guiterrez, Vince; Harney, Dylan; Koay, Yen Chin; Mach, John; Enamorado, Ignacio Navas; Pulpitel, Tamara; Wang, Yushi; Zhang, Jing; Zhang, Li; Spencer, Richard G.; Becker, Kevin G.; Egan, Josephine M.; Lakatta, Edward G.; O'Sullivan, John; Larance, Mark; LeCouteur, David G.; Cogger, Victoria C.; Gao, Bin; Fernandez-Hernando, Carlos; Cuervo, Ana Maria; de Cabo, Rafael
- Ewha Authors
- 서원효
- SCOPUS Author ID
- 서원효
- Issue Date
- 2020
- Journal Title
- CELL METABOLISM
- ISSN
- 1550-4131
1932-7420
- Citation
- CELL METABOLISM vol. 32, no. 2, pp. 203 - +
- Publisher
- CELL PRESS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Obesity is a top public health concern, and a molecule that safely treats obesity is urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties and helps protect against certain types of cancer. Here, we show that in mice disul-firam treatment prevented body weight gain and abrogated the adverse impact of an obesogenic diet on in-sulin responsiveness while mitigating liver steatosis and pancreatic islet hypertrophy. Additionally, disulfiram treatment reversed established diet-induced obesity and metabolic dysfunctions in middle-aged mice. Re-ductions in feeding efficiency and increases in energy expenditure were associated with body weight regu-lation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. Given the potent anti-obesogenic effects in rodents, repurposing disulfiram in the clinic could represent a new strategy to treat obesity and its metabolic comorbidities.
- DOI
- 10.1016/j.cmet.2020.04.019
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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