Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하헌주 | * |
dc.date.accessioned | 2021-08-12T16:30:55Z | - |
dc.date.available | 2021-08-12T16:30:55Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.issn | 1976-3786 | * |
dc.identifier.other | OAK-30006 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258591 | - |
dc.description.abstract | Beta 2 adrenergic receptor (beta(2)-AR)-agonists, widely used as bronchodilators, have demonstrated wide-spectrum anti-inflammatory properties in both immune and non-immune cells in various tissues. Their anti-inflammatory properties are mediated primarily, but not exclusively, via activation of the canonical beta(2)-AR signaling pathway (beta(2)-AR/cAMP/PKA). As non-canonical beta(2)-AR signaling also occurs, several inconsistent findings on the anti-inflammatory effect of beta(2)-agonists are notably present. Increasing amounts of evidence have unveiled the alternative mechanisms of the beta(2)-AR agonists in protecting the tissues against injuries, i.e., by augmenting mitochondria biogenesis and SIRT1 activity, and by attenuating fibrotic signaling. This review mainly covers the basic mechanisms of the anti-inflammatory effects of beta(2)-AR activation along with its limitations. Specifically, we summarized the role of beta(2)-AR signaling in regulating kidney function and in mediating the progression of acute and chronic kidney diseases. Given their versatile protective effects, beta(2)-agonists can be a promising avenue in the treatment of kidney diseases. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOC KOREA | * |
dc.subject | &#946 | * |
dc.subject | (2)-Adrenergic receptors | * |
dc.subject | (2)-Agonist | * |
dc.subject | Cyclic AMP | * |
dc.subject | GPCR | * |
dc.subject | Inflammation | * |
dc.subject | Kidney diseases | * |
dc.title | Activation of beta(2) adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases | * |
dc.type | Review | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 49 | * |
dc.relation.lastpage | 62 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/s12272-020-01280-9 | * |
dc.identifier.wosid | WOS:000587131100001 | * |
dc.author.google | Dorotea, Debra | * |
dc.author.google | Ha, Hunjoo | * |
dc.contributor.scopusid | 하헌주(7202277106) | * |
dc.date.modifydate | 20240422113229 | * |