Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2021-08-05T16:31:27Z | - |
dc.date.available | 2021-08-05T16:31:27Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0045-2068 | * |
dc.identifier.other | OAK-29584 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258557 | - |
dc.description.abstract | Psiguadial B (8), and its fluoro- (8a), chloro- (8b), and bromo- (8c) derivatives were synthesized using a sodium acetate-catalyzed single step coupling of three components: β-caryophyllene (5), diformylphloroglucinol (11), and benzaldehyde (12). These compounds efficiently and dose-dependently decreased H2O2-induced cell death, a quantitative marker of cell death, in primary cultures of mouse cortical neurons. Psiguadial B also decreased neuronal death and accumulation of ROS induced by FeCl2 in cortical cultures. The in vitro effects of these compounds in lipopolysaccharide (LPS)-induced expression of nitric oxide (NO), and TNF-α and IL-6 by suppressing the NF-κB pathway in immune cells demonstrated their antioxidative and anti-inflammatory activity. The present findings warrant further research on the development of psiguadial B-based neuroprotective agents for the treatment of neurodegenerative diseases, acute brain injuries and immunological disorders. © 2021 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Academic Press Inc. | * |
dc.subject | Anti-inflammatory effect | * |
dc.subject | Antioxidative effect | * |
dc.subject | Neuroprotective agent | * |
dc.subject | Psiguadial B | * |
dc.subject | Reactive oxygen species | * |
dc.subject | Short synthetic route | * |
dc.title | Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents | * |
dc.type | Article | * |
dc.relation.volume | 113 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Bioorganic Chemistry | * |
dc.identifier.doi | 10.1016/j.bioorg.2021.105027 | * |
dc.identifier.wosid | WOS:000663790400005 | * |
dc.identifier.scopusid | 2-s2.0-85108736253 | * |
dc.author.google | Man Kadayat T. | * |
dc.author.google | Eun Kim D. | * |
dc.author.google | Bong Lee S. | * |
dc.author.google | Jung K. | * |
dc.author.google | Eun Park S. | * |
dc.author.google | Hong J.-Y. | * |
dc.author.google | Kim J. | * |
dc.author.google | Shrestha A. | * |
dc.author.google | Kim D.-S. | * |
dc.author.google | An H. | * |
dc.author.google | Kim N. | * |
dc.author.google | Lee S.-J. | * |
dc.author.google | Kwon S. | * |
dc.author.google | Kim S. | * |
dc.author.google | Yeon Hwang J. | * |
dc.author.google | Hahn D. | * |
dc.author.google | Choi H. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Hyun Jeon Y. | * |
dc.author.google | Jin Hwang J. | * |
dc.author.google | Jin Cho S. | * |
dc.author.google | Chin J. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |