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공과대학
전자전기공학전공
Journal papers
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Implantable optrode array for optogenetic modulation and electrical neural recording
Title
Implantable optrode array for optogenetic modulation and electrical neural recording
Authors
Jeon S.
;
Lee Y.
;
Ryu D.
;
Cho Y.K.
;
Jun S.B.
;
Ji C.-H.
Ewha Authors
전상범
;
지창현
SCOPUS Author ID
전상범
; 지창현
Issue Date
2021
Journal Title
Micromachines
ISSN
2072-666X
Citation
Micromachines vol. 12, no. 6
Keywords
Channelrhodopsin
;
Electrode
;
Electrophysiology
;
Optogenetics
;
Optrode
Publisher
MDPI AG
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several tech-nological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophys-iological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
DOI
10.3390/mi12060725
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