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Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension
- Title
- Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension
- Authors
- Lee, Chan Joo; Hwang, Jinseub; Kang, Chae Young; Kim, Hyeon-Chang; Ryu, Dong-Ryeol; Ihm, Sang-Hyun; Kim, Yong-Jin; Shin, Jin-Ho; Pyun, Wook Bum; Kim, Changsoo; Park, Sungha
- Ewha Authors
- 류동열; 편욱범
- SCOPUS Author ID
- 류동열; 편욱범
- Issue Date
- 2021
- Journal Title
- JOURNAL OF HYPERTENSION
- ISSN
- 0263-6352
1473-5598
- Citation
- JOURNAL OF HYPERTENSION vol. 39, no. 8, pp. 1662 - 1669
- Keywords
- Alzheimer's disease; blood pressure; dementia; grade 1 hypertension; vascular dementia
- Publisher
- LIPPINCOTT WILLIAMS &
WILKINS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objective: High blood pressure (BP) increases the risk of dementia; however, few studies have reported on the risk of dementia in patients with low-risk, early-grade hypertension. We investigated the protective effect of controlled BP on risk of dementia in treated, low-risk, grade 1 hypertensive patients from the entire National Health Insurance Service National Health Examinee cohort. Methods: We selected grade 1 hypertension (140-159/90-99 mmHg) patients with low risk, diagnosed in 2005-2006. All patients (N = 128 665) were classified into controlled (average BP < 140/90 mmHg during the follow-up) and uncontrolled (average BP >= 140/90 mmHg) BP groups and followed up until 2015. The risk of dementia was estimated using Cox proportional hazard model after adjustments for propensity score. Results: Average BP was 131/81 mmHg in the controlled group (N = 49 408) and 144/87 mmHg in the uncontrolled group (N = 99 257). Overall dementia incidence rates in controlled and uncontrolled groups were 4.9 and 8.1 per 1000 person-year, respectively. The controlled group showed lower risk of overall dementia, Alzheimer's disease, and vascular dementia than the uncontrolled group. The controlled group had a low risk of vascular dementia at all ages, especially in the younger group (age <60). The optimal BP level associated with the lowest risk of dementia was 130 to less than 140 mmHg for SBP and 70 to less than 80 mmHg for DBP. Conclusion: We concluded that among even low-risk and grade 1 hypertension patients, controlled BP significantly reduced the risk of dementia, including Alzheimer's disease and vascular dementia.
- DOI
- 10.1097/HJH.0000000000002820
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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