Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류동열 | * |
dc.contributor.author | 편욱범 | * |
dc.date.accessioned | 2021-08-05T16:31:07Z | - |
dc.date.available | 2021-08-05T16:31:07Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0263-6352 | * |
dc.identifier.issn | 1473-5598 | * |
dc.identifier.other | OAK-29675 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258473 | - |
dc.description.abstract | Objective: High blood pressure (BP) increases the risk of dementia; however, few studies have reported on the risk of dementia in patients with low-risk, early-grade hypertension. We investigated the protective effect of controlled BP on risk of dementia in treated, low-risk, grade 1 hypertensive patients from the entire National Health Insurance Service National Health Examinee cohort. Methods: We selected grade 1 hypertension (140-159/90-99 mmHg) patients with low risk, diagnosed in 2005-2006. All patients (N = 128 665) were classified into controlled (average BP < 140/90 mmHg during the follow-up) and uncontrolled (average BP >= 140/90 mmHg) BP groups and followed up until 2015. The risk of dementia was estimated using Cox proportional hazard model after adjustments for propensity score. Results: Average BP was 131/81 mmHg in the controlled group (N = 49 408) and 144/87 mmHg in the uncontrolled group (N = 99 257). Overall dementia incidence rates in controlled and uncontrolled groups were 4.9 and 8.1 per 1000 person-year, respectively. The controlled group showed lower risk of overall dementia, Alzheimer's disease, and vascular dementia than the uncontrolled group. The controlled group had a low risk of vascular dementia at all ages, especially in the younger group (age <60). The optimal BP level associated with the lowest risk of dementia was 130 to less than 140 mmHg for SBP and 70 to less than 80 mmHg for DBP. Conclusion: We concluded that among even low-risk and grade 1 hypertension patients, controlled BP significantly reduced the risk of dementia, including Alzheimer's disease and vascular dementia. | * |
dc.language | English | * |
dc.publisher | LIPPINCOTT WILLIAMS & | * |
dc.publisher | WILKINS | * |
dc.subject | Alzheimer's disease | * |
dc.subject | blood pressure | * |
dc.subject | dementia | * |
dc.subject | grade 1 hypertension | * |
dc.subject | vascular dementia | * |
dc.title | Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 39 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1662 | * |
dc.relation.lastpage | 1669 | * |
dc.relation.journaltitle | JOURNAL OF HYPERTENSION | * |
dc.identifier.doi | 10.1097/HJH.0000000000002820 | * |
dc.identifier.wosid | WOS:000671996500021 | * |
dc.author.google | Lee, Chan Joo | * |
dc.author.google | Hwang, Jinseub | * |
dc.author.google | Kang, Chae Young | * |
dc.author.google | Kim, Hyeon-Chang | * |
dc.author.google | Ryu, Dong-Ryeol | * |
dc.author.google | Ihm, Sang-Hyun | * |
dc.author.google | Kim, Yong-Jin | * |
dc.author.google | Shin, Jin-Ho | * |
dc.author.google | Pyun, Wook Bum | * |
dc.author.google | Kim, Changsoo | * |
dc.author.google | Park, Sungha | * |
dc.contributor.scopusid | 류동열(56669926200) | * |
dc.contributor.scopusid | 편욱범(6508352922) | * |
dc.date.modifydate | 20240123092816 | * |