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Identification of Indicators for Preterm Birth Using Retinoid Metabolites
- Title
- Identification of Indicators for Preterm Birth Using Retinoid Metabolites
- Authors
- You, Young-Ah; Hwang, Soo-Yeon; Kim, Soo-Min; Park, Seojeong; Lee, Ga-In; Park, Sunwha; Ansari, AbuZar; Lee, Jeongae; Kwon, Youngjoo; Kim, Young-Ju
- Ewha Authors
- 김영주; 권영주; 유영아; 황수연; 박선화
- SCOPUS Author ID
- 김영주; 권영주; 유영아; 황수연; 박선화
- Issue Date
- 2021
- Journal Title
- METABOLITES
- ISSN
- 2218-1989
- Citation
- METABOLITES vol. 11, no. 7
- Keywords
- preterm birth; metabolomic analysis; retinoid metabolism; parturition; 13-cis-retinoic acid
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Metabolites reflect the biochemical dynamics for the maintenance of pregnancy and parturition. UPLC-Q/TOF-MS and LC-MS/MS metabolomics were performed to identify and validate the plasma metabolomic signatures of preterm birth (PTB). We recruited pregnant women between 16 and 40 weeks 5 days gestational age at Ewha Womans Mokdong Hospital for a nested case-control study. In untargeted UPLC-Q/TOF-MS, score plots of partial least-squares discriminant analysis clearly separated the PTB group from the term birth (TB, n = 10; PTB, n = 11). Fifteen metabolites were significantly different between the two groups, as indicated by a variable importance in projection >1 and p < 0.05. Metabolic pathways involving retinol, linoleic acid, d-arginine, and d-ornithine were associated with PTB. Verification by LC-MS/MS focused on retinol metabolism (TB, n = 39; PTB, n = 20). Retinol levels were significantly reduced in PTB compared to TB, while retinal palmitate, all-trans-retinal, and 13-cis-retinoic acid ((13)cis-RA) significantly increased (p < 0.05). Retinol-binding protein levels were also elevated in PTB. Additionally, all-trans-retinal (AUC 0.808, 95% CI: 0.683-0.933) and (13)cis-RA (AUC 0.826, 95% CI: 0.723-0.930) showed improved predictions for PTB-related retinol metabolites. This study suggests that retinoid metabolism improves the accuracy of PTB predictions and plays an important role in maintaining pregnancy and inducing early parturition.
- DOI
- 10.3390/metabo11070443
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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metabolites-11-00443-v2.pdf(2 MB)
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