Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영주 | * |
dc.contributor.author | 권영주 | * |
dc.contributor.author | 유영아 | * |
dc.contributor.author | 황수연 | * |
dc.contributor.author | 박선화 | * |
dc.date.accessioned | 2021-08-05T16:31:03Z | - |
dc.date.available | 2021-08-05T16:31:03Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2218-1989 | * |
dc.identifier.other | OAK-29703 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/258448 | - |
dc.description.abstract | Metabolites reflect the biochemical dynamics for the maintenance of pregnancy and parturition. UPLC-Q/TOF-MS and LC-MS/MS metabolomics were performed to identify and validate the plasma metabolomic signatures of preterm birth (PTB). We recruited pregnant women between 16 and 40 weeks 5 days gestational age at Ewha Womans Mokdong Hospital for a nested case-control study. In untargeted UPLC-Q/TOF-MS, score plots of partial least-squares discriminant analysis clearly separated the PTB group from the term birth (TB, n = 10; PTB, n = 11). Fifteen metabolites were significantly different between the two groups, as indicated by a variable importance in projection >1 and p < 0.05. Metabolic pathways involving retinol, linoleic acid, d-arginine, and d-ornithine were associated with PTB. Verification by LC-MS/MS focused on retinol metabolism (TB, n = 39; PTB, n = 20). Retinol levels were significantly reduced in PTB compared to TB, while retinal palmitate, all-trans-retinal, and 13-cis-retinoic acid ((13)cis-RA) significantly increased (p < 0.05). Retinol-binding protein levels were also elevated in PTB. Additionally, all-trans-retinal (AUC 0.808, 95% CI: 0.683-0.933) and (13)cis-RA (AUC 0.826, 95% CI: 0.723-0.930) showed improved predictions for PTB-related retinol metabolites. This study suggests that retinoid metabolism improves the accuracy of PTB predictions and plays an important role in maintaining pregnancy and inducing early parturition. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | preterm birth | * |
dc.subject | metabolomic analysis | * |
dc.subject | retinoid metabolism | * |
dc.subject | parturition | * |
dc.subject | 13-cis-retinoic acid | * |
dc.title | Identification of Indicators for Preterm Birth Using Retinoid Metabolites | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | METABOLITES | * |
dc.identifier.doi | 10.3390/metabo11070443 | * |
dc.identifier.wosid | WOS:000676283200001 | * |
dc.identifier.scopusid | 2-s2.0-85110823405 | * |
dc.author.google | You, Young-Ah | * |
dc.author.google | Hwang, Soo-Yeon | * |
dc.author.google | Kim, Soo-Min | * |
dc.author.google | Park, Seojeong | * |
dc.author.google | Lee, Ga-In | * |
dc.author.google | Park, Sunwha | * |
dc.author.google | Ansari, AbuZar | * |
dc.author.google | Lee, Jeongae | * |
dc.author.google | Kwon, Youngjoo | * |
dc.author.google | Kim, Young-Ju | * |
dc.contributor.scopusid | 김영주(55801681000) | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.contributor.scopusid | 유영아(35212686400) | * |
dc.contributor.scopusid | 황수연(57207836844) | * |
dc.contributor.scopusid | 박선화(57218565331) | * |
dc.date.modifydate | 20240429111118 | * |