Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.contributor.author | 박영미 | * |
dc.contributor.author | 조원경 | * |
dc.date.accessioned | 2021-06-07T16:31:47Z | - |
dc.date.available | 2021-06-07T16:31:47Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2233-6079 | * |
dc.identifier.issn | 2233-6087 | * |
dc.identifier.other | OAK-29310 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257680 | - |
dc.description.abstract | Background: Obesity and type 2 diabetes mellitus are world-wide health problems, and lack of understanding of their linking mechanism is one reason for limited treatment options. We determined if genetic deletion of vimentin, a type 3 intermediate filament, affects obesity and type 2 diabetes mellitus. Methods: We fed vimentin-null (Vim(-/-)) mice and wild-type mice a high-fat diet (HFD) for 10 weeks and measured weight change, adiposity, blood lipids, and glucose. We performed intraperitoneal glucose tolerance tests and measured CD36, a major fatty acid translocase, and glucose transporter type 4 (GLUT4) in adipocytes from both groups of mice. Results: Vim(-/-) mice fed an HFD showed less weight gain, less adiposity, improved glucose tolerance, and lower serum level of fasting glucose. However, serum triglyceride and non-esterified fatty acid levels were higher in Vim(-/-) mice than in wild-type mice. Vimentin-null adipocytes showed 41.1% less CD36 on plasma membranes, 27% less uptake of fatty acids, and 50.3% less GLUT4, suggesting defects in intracellular trafficking of these molecules. Conclusion: We concluded that vimentin deficiency prevents obesity and insulin resistance in mice fed an HFD and suggest vimentin as a central mediator linking obesity and type 2 diabetes mellitus. | * |
dc.language | English | * |
dc.publisher | KOREAN DIABETES ASSOC | * |
dc.subject | CD36 antigens | * |
dc.subject | Glucose transporter type 4 | * |
dc.subject | Insulin resistance | * |
dc.subject | Obesity | * |
dc.subject | Vimentin | * |
dc.title | Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 45 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 97 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | DIABETES & METABOLISM JOURNAL | * |
dc.identifier.doi | 10.4093/dmj.2019.0198 | * |
dc.identifier.wosid | WOS:000625390100010 | * |
dc.author.google | Kim, SeoYeon | * |
dc.author.google | Kim, Inyeong | * |
dc.author.google | Cho, Wonkyoung | * |
dc.author.google | Oh, Goo Taeg | * |
dc.author.google | Park, Young Mi | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.contributor.scopusid | 박영미(7405372677) | * |
dc.contributor.scopusid | 조원경(56747102200) | * |
dc.date.modifydate | 20240429141525 | * |