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Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances
- Title
- Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances
- Authors
- Rahman M.A.; Dash R.; Sohag A.A.M.; Alam M.; Rhim H.; Ha H.; Moon I.S.; Uddin M.J.; Hannan M.A.
- Ewha Authors
- 하헌주; Md Jamal Uddin
- SCOPUS Author ID
- 하헌주; Md Jamal Uddin
- Issue Date
- 2021
- Journal Title
- Marine drugs
- ISSN
- 1660-3397
- Citation
- Marine drugs vol. 19, no. 3
- Keywords
- cholesterol homeostasis; fucosterol; inflammation; marine steroids; neurodegeneration; oxidative stress
- Publisher
- NLM (Medline)
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer's agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer's activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD.
- DOI
- 10.3390/md19030167
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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