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Poly(Ethylene glycol)-poly(l-alanine)/hyaluronic acid complex as a 3d platform for understanding cancer cell migration in the tumor microenvironment
- Title
- Poly(Ethylene glycol)-poly(l-alanine)/hyaluronic acid complex as a 3d platform for understanding cancer cell migration in the tumor microenvironment
- Authors
- Sim J.; Lee H.J.; Jeong B.; Park M.H.
- Ewha Authors
- 정병문
- SCOPUS Author ID
- 정병문
- Issue Date
- 2021
- Journal Title
- Polymers
- ISSN
- 2073-4360
- Citation
- Polymers vol. 13, no. 7
- Keywords
- 3D matrix; Migration; Multicellular spheroid; Polymer complex; Tumor microenvironment
- Publisher
- MDPI AG
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled structure, which provides a biocompatible 3D environment for the cells. Multicellular spheroids were formed on the optimized plate and were observed as cell migration from a spheroid within a 3D matrix, such as the invasive and metastatic cancer of TME. This study suggests a new 3D platform using polymer complexes and the importance of tumor complexities, including various cell types and microenvironments. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
- DOI
- 10.3390/polym13071042
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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