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의과대학
의학과
Journal papers
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Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity
Title
Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity
Authors
Bota-Rabassedas N.
;
Banerjee P.
;
Niu Y.
;
Cao W.
;
Luo J.
;
Xi Y.
;
Tan X.
;
Sheng K.
;
Ahn Y.-H.
;
Lee S.
;
Parra E.R.
;
Rodriguez-Canales J.
;
Albritton J.
;
Weiger M.
;
Liu X.
;
Guo H.-F.
;
Yu J.
;
Rodriguez B.L.
;
Firestone J.J.A.
;
Mino B.
;
Creighton C.J.
;
Solis L.M.
;
Villalobos P.
;
Raso M.G.
;
Sazer D.W.
;
Gibbons D.L.
;
Russell W.K.
;
Longmore G.D.
;
Wistuba I.I.
;
Wang J.
;
Chapman H.A.
;
Miller J.S.
;
Zong C.
;
Kurie J.M.
Ewha Authors
안영호
SCOPUS Author ID
안영호
Issue Date
2021
Journal Title
Cell Reports
ISSN
2211-1247
Citation
Cell Reports vol. 35, no. 3
Keywords
cancer-associated fibroblast
;
EMT
;
invasion
;
lung cancer
;
metastasis
;
microRNA
;
secretion
;
single-cell RNA sequencing
;
tumor microenvironment
Publisher
Elsevier B.V.
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis. © 2021 The Author(s)
DOI
10.1016/j.celrep.2021.109009
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