Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안영호 | * |
dc.date.accessioned | 2021-06-07T16:31:23Z | - |
dc.date.available | 2021-06-07T16:31:23Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2211-1247 | * |
dc.identifier.other | OAK-29375 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257616 | - |
dc.description.abstract | Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis. © 2021 The Author(s) | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | cancer-associated fibroblast | * |
dc.subject | EMT | * |
dc.subject | invasion | * |
dc.subject | lung cancer | * |
dc.subject | metastasis | * |
dc.subject | microRNA | * |
dc.subject | secretion | * |
dc.subject | single-cell RNA sequencing | * |
dc.subject | tumor microenvironment | * |
dc.title | Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 35 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Cell Reports | * |
dc.identifier.doi | 10.1016/j.celrep.2021.109009 | * |
dc.identifier.wosid | WOS:000642161700007 | * |
dc.identifier.scopusid | 2-s2.0-85104303878 | * |
dc.author.google | Bota-Rabassedas N. | * |
dc.author.google | Banerjee P. | * |
dc.author.google | Niu Y. | * |
dc.author.google | Cao W. | * |
dc.author.google | Luo J. | * |
dc.author.google | Xi Y. | * |
dc.author.google | Tan X. | * |
dc.author.google | Sheng K. | * |
dc.author.google | Ahn Y.-H. | * |
dc.author.google | Lee S. | * |
dc.author.google | Parra E.R. | * |
dc.author.google | Rodriguez-Canales J. | * |
dc.author.google | Albritton J. | * |
dc.author.google | Weiger M. | * |
dc.author.google | Liu X. | * |
dc.author.google | Guo H.-F. | * |
dc.author.google | Yu J. | * |
dc.author.google | Rodriguez B.L. | * |
dc.author.google | Firestone J.J.A. | * |
dc.author.google | Mino B. | * |
dc.author.google | Creighton C.J. | * |
dc.author.google | Solis L.M. | * |
dc.author.google | Villalobos P. | * |
dc.author.google | Raso M.G. | * |
dc.author.google | Sazer D.W. | * |
dc.author.google | Gibbons D.L. | * |
dc.author.google | Russell W.K. | * |
dc.author.google | Longmore G.D. | * |
dc.author.google | Wistuba I.I. | * |
dc.author.google | Wang J. | * |
dc.author.google | Chapman H.A. | * |
dc.author.google | Miller J.S. | * |
dc.author.google | Zong C. | * |
dc.author.google | Kurie J.M. | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.date.modifydate | 20240222132209 | * |