Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이대기 | * |
dc.date.accessioned | 2021-06-07T16:31:19Z | - |
dc.date.available | 2021-06-07T16:31:19Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2072-6694 | * |
dc.identifier.other | OAK-29387 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257604 | - |
dc.description.abstract | PGC1α oppositely regulates cancer metastasis in melanoma, breast, and pancreatic cancer; however, little is known about its impact on lung cancer metastasis. Transcriptome and in vivo xenograft analysis show that a decreased PGC1α correlates with the epithelial–mesenchymal transition (EMT) and lung cancer metastasis. The deletion of a single Pgc1α allele in mice promotes bone metastasis of KrasG12D-driven lung cancer. Mechanistically, PGC1α predominantly activates ID1 expression, which interferes with TCF4-TWIST1 cooperation during EMT. Bioinformatic and clinical studies have shown that PGC1α and ID1 are downregulated in lung cancer, and correlate with a poor survival rate. Our study indicates that TCF4-TWIST1-mediated EMT, which is regulated by the PGC1α-ID1 transcriptional axis, is a potential diagnostic and therapeutic target for metastatic lung cancer. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | * |
dc.description.sponsorship | Shin, H.-W.; Obstructive Upper airway Research (OUaR) Laboratory, South Korea; email: charlie@snu.ac.kr Shin, H.-W.; Department of Biomedical Sciences, South Korea; email: charlie@snu.ac.kr Shin, H.-W.; Cancer Research Institute, South Korea; email: charlie@snu.ac.kr Shin, D.H.; Research Institute, South Korea; email: dhshin@ncc.re.kr Lim, J.-H.; Department of Biomedical Chemistry, South Korea; email: jhlim@kku.ac.kr Lim, J.-H.; Department of Applied Life Science, South Korea; email: jhlim@kku.ac.kr Lim, J.-H.; Diabetes and Bio-Research Center, South Korea; email: jhlim@kku.ac.kr | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | EMT | * |
dc.subject | ID1 | * |
dc.subject | Lung cancer | * |
dc.subject | Metastasis | * |
dc.subject | PGC1α | * |
dc.subject | TCF4 | * |
dc.subject | TWIST1 | * |
dc.title | Pgc1α loss promotes lung cancer metastasis through epithelial-mesenchymal transition | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Cancers | * |
dc.identifier.doi | 10.3390/cancers13081772 | * |
dc.identifier.wosid | WOS:000644004300001 | * |
dc.identifier.scopusid | 2-s2.0-85103836185 | * |
dc.author.google | Oh T.-I. | * |
dc.author.google | Lee M. | * |
dc.author.google | Lee Y.-M. | * |
dc.author.google | Kim G.-H. | * |
dc.author.google | Lee D. | * |
dc.author.google | You J.S. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Choi M. | * |
dc.author.google | Jang H. | * |
dc.author.google | Park Y.-M. | * |
dc.author.google | Shin H.-W. | * |
dc.author.google | Shin D.H. | * |
dc.author.google | Lim J.-H. | * |
dc.contributor.scopusid | 이대기(37047040400) | * |
dc.date.modifydate | 20231120165418 | * |