Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽혜선 | * |
dc.contributor.author | 송곤진 | * |
dc.date.accessioned | 2021-06-07T16:31:06Z | - |
dc.date.available | 2021-06-07T16:31:06Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1664-2392 | * |
dc.identifier.other | OAK-29425 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257568 | - |
dc.description.abstract | Background: The ATP-binding cassette transporter A1 (ABCA1) is likely associated with the risk of type 2 diabetes mellitus (T2DM) via β cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the ABCA1 69C>T polymorphism and the risk of T2DM through a systematic review and meta-analysis. Materials and Methods: The PubMed, Web of Science, and Embase databases were searched for qualified studies published until August 2020. Studies that included the association between the ABCA1 69C>T polymorphism and the risk of T2DM were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated. Results: We analyzed data from a total of 10 studies involving 17,742 patients. We found that the CC or CT genotype was associated with increased risk of T2DM than the TT genotype (OR, 1.41; 95% CI, 1.02-1.93). In the Asian population, the C allele carriers had a higher risk of T2DM than those with the TT genotype; the ORs of the CC and CT genotypes were 1.80 (95% CI, 1.21-2.68) and 1.61 (95% CI, and 1.29-2.01), respectively. Conclusions: This meta-analysis confirmed that the ABCA1 69C>T genotype showed a decrease risk of T2DM compared to the CC or CT genotypes. © Copyright © 2021 Yoon, Lee, Song, Yee, Song and Gwak. | * |
dc.language | English | * |
dc.publisher | Frontiers Media S.A. | * |
dc.subject | ABCA1 69 C>T | * |
dc.subject | meta-analysis | * |
dc.subject | polymorphism | * |
dc.subject | systematic review | * |
dc.subject | type 2 diabetes mellitus | * |
dc.title | ABCA1 69C>T Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Systematic Review and Updated Meta-Analysis | * |
dc.type | Review | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Frontiers in Endocrinology | * |
dc.identifier.doi | 10.3389/fendo.2021.639524 | * |
dc.identifier.wosid | WOS:000648053200001 | * |
dc.identifier.scopusid | 2-s2.0-85105444732 | * |
dc.author.google | Yoon H.Y. | * |
dc.author.google | Lee M.H. | * |
dc.author.google | Song Y. | * |
dc.author.google | Yee J. | * |
dc.author.google | Song G. | * |
dc.author.google | Gwak H.S. | * |
dc.contributor.scopusid | 송곤진(57208326415) | * |
dc.date.modifydate | 20240422115307 | * |