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Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors
- Title
- Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors
- Authors
- Won K.-B.; Heo R.; Park H.-B.; Lee B.K.; Lin F.Y.; Hadamitzky M.; Kim Y.-J.; Sung J.M.; Conte E.; Andreini D.; Pontone G.; Budoff M.J.; Gottlieb I.; Chun E.J.; Cademartiri F.; Maffei E.; Marques H.; de Araújo Gonçalves P.; Leipsic J.A.; Lee S.-E.; Shin S.; Choi J.H.; Virmani R.; Samady H.; Chinnaiyan K.; Berman D.S.; Narula J.; Shaw L.J.; Bax J.J.; Min J.K.; Chang H.-J.
- Ewha Authors
- 신상훈; 이상은
- SCOPUS Author ID
- 신상훈; 이상은
- Issue Date
- 2021
- Journal Title
- Atherosclerosis
- ISSN
- 0021-9150
- Citation
- Atherosclerosis vol. 324, pp. 46 - 51
- Keywords
- Atherogenic index of plasma; Atherosclerosis; Coronary artery disease; Coronary computed tomography angiography
- Publisher
- Elsevier Ireland Ltd
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). Methods: A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles. Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02–2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors. © 2021 Elsevier B.V.
- DOI
- 10.1016/j.atherosclerosis.2021.03.009
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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