View : 913 Download: 76
Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
- Title
- Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
- Authors
- Park, Doo Ri; Kim, Jihee; Kim, Gyeong Min; Lee, Haeseung; Kim, Minhee; Hwang, Donghyun; Lee, Hana; Kim, Han-Sung; Kim, Wankyu; Park, Min Chan; Shim, Hyunbo; Lee, Soo Young
- Ewha Authors
- 이수영; 심현보; 김완규; 박두리; 이해승
- SCOPUS Author ID
- 이수영; 심현보; 김완규; 박두리
- Issue Date
- 2020
- Journal Title
- NATURE COMMUNICATIONS
- ISSN
- 2041-1723
- Citation
- NATURE COMMUNICATIONS vol. 11, no. 1
- Publisher
- NATURE RESEARCH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently available. Although OA is primarily characterized by cartilage destruction, our understanding of the processes controlling OA progression is poor. Here, we report the association of OA with increased levels of osteoclast-associated receptor (OSCAR), an immunoglobulin-like collagen-recognition receptor. In mice, OSCAR deletion abrogates OA manifestations, such as articular cartilage destruction, subchondral bone sclerosis, and hyaline cartilage loss. These effects are a result of decreased chondrocyte apoptosis, which is caused by the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in induced OA. Treatments with human OSCAR-Fc fusion protein attenuates OA pathogenesis caused by experimental OA. Thus, this work highlights the function of OSCAR as a catabolic regulator of OA pathogenesis, indicating that OSCAR blockade is a potential therapy for OA.
- DOI
- 10.1038/s41467-020-18208-y
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
- Files in This Item:
-
s41467-020-18208-y.pdf(5.08 MB)
Download
- Export
- RIS (EndNote)
- XLS (Excel)
- XML