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Ensuring both velocity and spatial responses robust to B0/B1+ field inhomogeneities for velocity-selective arterial spin labeling through dynamic phase-cycling
- Title
- Ensuring both velocity and spatial responses robust to B0/B1+ field inhomogeneities for velocity-selective arterial spin labeling through dynamic phase-cycling
- Authors
- Liu D.; Li W.; Xu F.; Zhu D.; Shin T.; Qin Q.
- Ewha Authors
- 신태훈
- SCOPUS Author ID
- 신태훈
- Issue Date
- 2021
- Journal Title
- Magnetic Resonance in Medicine
- ISSN
- 0740-3194
- Citation
- Magnetic Resonance in Medicine vol. 85, no. 5, pp. 2723 - 2734
- Keywords
- arterial spin labeling; B1+ field inhomogeneity; B0 field inhomogeneity; cerebral blood flow; velocity-selective inversion
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: To evaluate both velocity and spatial responses of velocity-selective arterial spin labeling (VS-ASL), using velocity-insensitive and velocity-compensated waveforms for control modules, as well as a novel dynamic phase-cycling approach, at different B0/ (Formula presented.) field inhomogeneities. Methods: In the presence of imperfect refocusing, the mechanism of phase-cycling the refocusing pulses through four dynamics was first theoretically analyzed with the conventional velocity-selective saturation (VSS) pulse train. Numerical simulations were then deployed to compare the performance of the Fourier-transform based velocity-selective inversion (FT-VSI) with these three different schemes in terms of both velocity and spatial responses under various B0/ (Formula presented.) conditions. Phantom and human brain scans were performed to evaluate the three methods at (Formula presented.) scales of 0.8, 1.0, and 1.2. Results: The simulations of FT-VSI showed that, under nonuniform B0/ (Formula presented.) conditions, the scheme with velocity-insensitive control was susceptible to DC bias of the static spins as systematic error, while the scheme with velocity-compensated control had deteriorated velocity-selective labeling profiles and, thus, reduced labeling efficiency. Through numerical simulation, phantom scans, and brain perfusion measurements, the dynamic phase-cycling method demonstrated considerable improvements over these issues. Conclusion: The proposed dynamic phase-cycling approach was demonstrated for the velocity-selective label and control modules with both velocity and spatial responses robust to a wide range of B0 and (Formula presented.) field inhomogeneities. © 2020 International Society for Magnetic Resonance in Medicine
- DOI
- 10.1002/mrm.28622
- Appears in Collections:
- 공과대학 > 휴먼기계바이오공학과 > Journal papers
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