Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 류인균 | * |
dc.date.accessioned | 2021-02-25T16:31:45Z | - |
dc.date.available | 2021-02-25T16:31:45Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-28902 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/257143 | - |
dc.description.abstract | Serotonin (5-HT) plays an important role in cerebrovascular homeostasis and psychiatric disorders, including suicidality. Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles of SLC6A4 methylation and suicidal ideation (SI) in long-term outcomes of stroke have not been evaluated. We investigated the independent and interactive effects of SLC6A4 methylation and SI immediately after stroke on long-term outcomes. Blood SLC6A4 methylation status and SI based on the suicide item of the Montgomery–Åsberg Depression Rating Scale were assessed in 278 patients at 2 weeks after stroke. After the index stroke, cerebro-cardiovascular events by SLC6A4 methylation status and SI were investigated over an 8–14-year follow-up period and using Cox regression models adjusted for a range of covariates. SLC6A4 hypermethylation and SI within 2 weeks of stroke both predicted worse long-term outcomes, independent of covariates. A significant interaction effect of SI and the methylation status of CpG 4 on long-term stroke outcomes was also identified. The association between SLC6A4 methylation and long-term adverse outcomes may be strengthened in the presence of SI within 2 weeks after stroke. Evaluation of methylation and SI status during the acute phase can be helpful when assessing stroke patients. © 2021, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Research | * |
dc.title | Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-021-81854-9 | * |
dc.identifier.wosid | WOS:000617703500008 | * |
dc.identifier.scopusid | 2-s2.0-85100236957 | * |
dc.author.google | Kang H.-J. | * |
dc.author.google | Lee E.-H. | * |
dc.author.google | Kim J.-W. | * |
dc.author.google | Kim S.-W. | * |
dc.author.google | Shin I.-S. | * |
dc.author.google | Kim J.-T. | * |
dc.author.google | Park M.-S. | * |
dc.author.google | Cho K.-H. | * |
dc.author.google | Han J.-S. | * |
dc.author.google | Lyoo I.K. | * |
dc.author.google | Kim J.-M. | * |
dc.contributor.scopusid | 류인균(55664289900) | * |
dc.date.modifydate | 20240220114752 | * |