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Behavioral changes and gene profile alterations after chronic 1,950-MHz radiofrequency exposure: An observation in C57BL/6 mice
- Title
- Behavioral changes and gene profile alterations after chronic 1,950-MHz radiofrequency exposure: An observation in C57BL/6 mice
- Authors
- Jeong, Ye Ji; Son, Yeonghoon; Choi, Hyung-Do; Kim, Nam; Lee, Yun-Sil; Ko, Young-Gyu; Lee, Hae-June
- Ewha Authors
- 이윤실
- SCOPUS Author ID
- 이윤실
- Issue Date
- 2020
- Journal Title
- BRAIN AND BEHAVIOR
- ISSN
- 2162-3279
- Citation
- BRAIN AND BEHAVIOR vol. 10, no. 11
- Keywords
- behavioral alteration; gene profiling; memory; neurogenesis; RF-EMF
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Introduction Due to public concerns about deleterious biological consequences of radiofrequency electromagnetic fields (RF-EMF), the potential effects of RF-EMF on the central nervous system have received wide consideration. Methods Here, two groups of C57BL/6 mice, aged 2 and 12 months, were exposed to 1,950-MHz RF-EMF at a specific absorption rate of 5.0 W/kg for chronic periods (2 hr/day and 5 days/week for 8 months). Behavioral changes were then assessed in the mice at 10 months (sham- or RF-10M) and 20 months (sham- or RF-20M), on the open-field test, the Y-maze test, and an object recognition memory task, while biological effects were analyzed via microarray gene profiling of the hippocampus. Results Open-field test results showed a decrease in the time duration spent at the center while there was a decrease in enhanced memory shown by the Y-maze test and the novel object recognition test in the RF-20M mice, compared to sham-exposed mice, but no significant changes in the RF-10M group. Based on a 2-fold change cutoff, the microarray data revealed that 15 genes, which are listed as being involved in neurogenesis on Gene Ontology, were altered in both groups. Quantitative real-time PCR for validation showed increased expression ofEpha8andWnt6in the hippocampi of RF-20M group mice, although 13 additional genes showed no significant changes following RF-EMF exposure. Conclusion Therefore, cognitive enhancement following chronic exposure for 8 months to RF-EMF from middle age may be associated with increases in neurogenesis-related signals in the hippocampus of C57BL/6 mice.
- DOI
- 10.1002/brb3.1815
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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Brain and Behavior - 2020 - Jeong - Behavioral changes and gene profile alterations after chronic 1 950‐MHz radiofrequency.pdf(1.15 MB)
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