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The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
- Title
- The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
- Authors
- Zhang, Ying; Park, Jiyoung; Han, Seong-Jeong; Park, Iha; Thang Nguyen Huu; Kim, Jong-Suk; Woo, Hyun Ae; Lee, Seung-Rock
- Ewha Authors
- 우현애
- SCOPUS Author ID
- 우현애
- Issue Date
- 2021
- Journal Title
- FREE RADICAL BIOLOGY AND MEDICINE
- ISSN
- 0891-5849
1873-4596
- Citation
- FREE RADICAL BIOLOGY AND MEDICINE vol. 162, pp. 141 - 148
- Keywords
- Alcohol; Hepatic steatosis; Alcoholic fatty liver disease; PTEN; Reactive oxygen species; Peroxiredoxin III
- Publisher
- ELSEVIER SCIENCE INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of ROS and the underlying cellular mechanisms are unknown. Here, we investigate roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in the alcoholic fatty liver. Alcohol-induced mitochondrial oxidative stress was found to contribute to reversible oxidation of PTEN, which results in Akt and MAPK hyperactivation with elevated levels of the lipogenesis regulators SREBP1c and PPAR gamma. Moreover, mitochondrial peroxiredoxin III was found to have antagonistic effects on lipogenesis via the redox regulation of PTEN by removing ROS, upon alcohol exposure. This study demonstrated that redox regulation of PTEN and peroxiredoxin III play crucial roles in the development of AFLD.
- DOI
- 10.1016/j.freeradbiomed.2020.11.022
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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