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Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells
- Title
- Antaroide, a Novel Natural Nine-Membered Macrolide, Inhibits Melanin Biosynthesis in B16F10 Murine Melanoma Cells
- Authors
- Ryu, Min-Ji; Baek, Eun-Ki; Kim, Soyeon; Seong, Chi Nam; Yang, Inho; Lim, Kyung-Min; Nam, Sang-Jip
- Ewha Authors
- 임경민; 남상집
- SCOPUS Author ID
- 임경민
; 남상집![scopus](/images/layout/icon2.png)
- Issue Date
- 2021
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- ISSN
- 1976-9148
2005-4483
- Citation
- BIOMOLECULES & THERAPEUTICS vol. 29, no. 1, pp. 98 - 103
- Keywords
- Streptomyces sp.; Nine-membered macrolide; Marine natural product; Melanin synthesis inhibitor; Skin whitening agent
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Indexed
- SCIE; SCOPUS; KCI
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the a-melanocyte stimulating hormone (a-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.
- DOI
- 10.4062/biomolther.2020.064
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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