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Fumonisin B1-Induced Toxicity Was Not Exacerbated in Glutathione Peroxidase-1/Catalase Double Knock Out Mice
- Title
- Fumonisin B1-Induced Toxicity Was Not Exacerbated in Glutathione Peroxidase-1/Catalase Double Knock Out Mice
- Authors
- Yayeh, Taddesse; Jeong, Ha Ram; Park, Yoon Soo; Moon, Sohyeon; Sur, Bongjun; Yoo, Hwan-Soo; Oh, Seikwan
- Ewha Authors
- 오세관
- SCOPUS Author ID
- 오세관
- Issue Date
- 2021
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- ISSN
- 1976-9148
2005-4483
- Citation
- BIOMOLECULES & THERAPEUTICS vol. 29, no. 1, pp. 52 - 57
- Keywords
- Fumonisin B1; Catalase; Glutathione peroxidase1; Sphingosine; Sphinganine
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotransferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice.
- DOI
- 10.4062/biomolther.2020.062
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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