Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2021-01-28T16:30:03Z | - |
dc.date.available | 2021-01-28T16:30:03Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.issn | 2005-4483 | * |
dc.identifier.other | OAK-28755 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/256225 | - |
dc.description.abstract | Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotransferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | * |
dc.subject | Fumonisin B1 | * |
dc.subject | Catalase | * |
dc.subject | Glutathione peroxidase1 | * |
dc.subject | Sphingosine | * |
dc.subject | Sphinganine | * |
dc.title | Fumonisin B1-Induced Toxicity Was Not Exacerbated in Glutathione Peroxidase-1/Catalase Double Knock Out Mice | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 52 | * |
dc.relation.lastpage | 57 | * |
dc.relation.journaltitle | BIOMOLECULES & THERAPEUTICS | * |
dc.identifier.doi | 10.4062/biomolther.2020.062 | * |
dc.identifier.wosid | WOS:000652471600006 | * |
dc.identifier.scopusid | 2-s2.0-85099456176 | * |
dc.author.google | Yayeh, Taddesse | * |
dc.author.google | Jeong, Ha Ram | * |
dc.author.google | Park, Yoon Soo | * |
dc.author.google | Moon, Sohyeon | * |
dc.author.google | Sur, Bongjun | * |
dc.author.google | Yoo, Hwan-Soo | * |
dc.author.google | Oh, Seikwan | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |