Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하헌주 | * |
dc.date.accessioned | 2021-01-28T16:30:02Z | - |
dc.date.available | 2021-01-28T16:30:02Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.issn | 2005-4483 | * |
dc.identifier.other | OAK-28758 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/256222 | - |
dc.description.abstract | Src family kinases (SFKs), an important group of non-receptor tyrosine kinases, are suggested to be excessively activated during various types of tissue fibrosis. The present study investigated the effect of KF-1607, an orally active and a newly synthesized Src kinase inhibitor (SKI) with proposed low toxicity, in preventing the progression of renal interstitial fibrosis. Unilateral ureteral obstruction (UUO) surgery was performed in 6-week-old male C57BL/6 mice to induce renal interstitial fibrosis. Either KF-1607 (30 mg/kg, oral gavage) or PP2 (2 mg/kg, intraperitoneal injection), a common experimental SKI, was administered to mice for seven days, started one day prior to surgery. UUO injury-induced SFK expression, including Src, Fyn, and Lyn kinase. SFK inhibition by KF-1607 prevented the progression of tubular injury in UUO mice, as indicated by decreases in albuminuria, urinary KIM-1 excretion, and kidney NGAL protein expression. Renal tubulointerstitial fibrosis was attenuated in response to KF-1607, as shown by decreases in alpha-SMA, collagen I and IV protein expression, along with reduced Masson's trichrome and collagen-I staining in kidneys. KF-1607 also inhibited inflammation in the UUO kidney, as exhibited by reductions in F4/80 positive-staining and protein expression of p-NF kappa B and ICAM. Importantly, the observed effects of KF-1607 were similar to those of PP2. A new pan Src kinase inhibitor, KF-1607, is a potential pharmaceutical agent to prevent the progression of renal interstitial fibrosis. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | * |
dc.subject | Src kinase | * |
dc.subject | Src kinase inhibitor | * |
dc.subject | Ureteral obstruction | * |
dc.subject | Renal fibrosis | * |
dc.subject | Chronic kidney disease | * |
dc.title | KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 41 | * |
dc.relation.lastpage | 51 | * |
dc.relation.journaltitle | BIOMOLECULES & THERAPEUTICS | * |
dc.identifier.doi | 10.4062/biomolther.2020.088 | * |
dc.identifier.wosid | WOS:000652471600005 | * |
dc.identifier.scopusid | 2-s2.0-85099470283 | * |
dc.author.google | Dorotea, Debra | * |
dc.author.google | Lee, Seungyeon | * |
dc.author.google | Lee, Sun Joo | * |
dc.author.google | Lee, Gayoung | * |
dc.author.google | Son, Jung Beom | * |
dc.author.google | Choi, Hwan Geun | * |
dc.author.google | Ahn, Sung-Min | * |
dc.author.google | Ha, Hunjoo | * |
dc.contributor.scopusid | 하헌주(7202277106) | * |
dc.date.modifydate | 20240422113229 | * |