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Regulation of Deubiquitinating Enzymes by Post-Translational Modifications
- Title
- Regulation of Deubiquitinating Enzymes by Post-Translational Modifications
- Authors
- Das, Tanuza; Shin, Sang Chul; Song, Eun Joo; Kim, Eunice EunKyeong
- Ewha Authors
- 송은주
- SCOPUS Author ID
- 송은주
- Issue Date
- 2020
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ISSN
- 1422-0067
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol. 21, no. 11
- Keywords
- post-translational modification (PTM); deubiquitinase (DUB); deubiquitinating enzyme; activity; localization; interaction; disease
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes, and the enzymes involved are tightly regulated by multiple factors including posttranslational modifications like most other proteins. Dysfunction or misregulation of these enzymes could have dramatic physiological consequences, sometimes leading to diseases. Therefore, it is important to have a clear understanding of these regulatory processes. Here, we have reviewed the posttranslational modifications of deubiquitinating enzymes and their consequences on the catalytic activity, stability, abundance, localization, and interaction with the partner proteins.
- DOI
- 10.3390/ijms21114028
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
-
ijms-21-04028-v3.pdf(2.23 MB)
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